Establishment and application of a novel patient-derived KIAA1549:BRAF-driven pediatric pilocytic astrocytoma model for preclinical drug testing

Pilocytic astrocytoma (PA) is the most frequent pediatric brain tumor. Activation of the MAPK pathway is well established as the oncogenic driver of the disease. It is most frequently caused by KIAA1549:BRAF fusions, and leads to oncogene induced senescence (OIS). OIS is thought to be a major reason...

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Detalles Bibliográficos
Autores principales: Selt, Florian, Hohloch, Juliane, Hielscher, Thomas, Sahm, Felix, Capper, David, Korshunov, Andrey, Usta, Diren, Brabetz, Sebastian, Ridinger, Johannes, Ecker, Jonas, Oehme, Ina, Gronych, Jan, Marquardt, Viktoria, Pauck, David, Bächli, Heidi, Stiles, Charles D, von Deimling, Andreas, Remke, Marc, Schuhmann, Martin U, Pfister, Stefan M, Brummer, Tilman, Jones, David T.W., Witt, Olaf, Milde, Till
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355278/
https://www.ncbi.nlm.nih.gov/pubmed/28002790
http://dx.doi.org/10.18632/oncotarget.14004

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