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Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells

Receptor-PI3K-mTORC1 signaling and fatty acid synthase (FASN)-regulated lipid biosynthesis harbor numerous drug targets and are molecularly connected. We hypothesize that unraveling the mechanisms of pathway cross-talk will be useful for designing novel co-targeting strategies for ovarian cancer (OC...

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Detalles Bibliográficos
Autores principales:	Wagner, Renate, Stübiger, Gerald, Veigel, Daniel, Wuczkowski, Michael, Lanzerstorfer, Peter, Weghuber, Julian, Karteris, Emmanouil, Nowikovsky, Karin, Wilfinger-Lutz, Nastasia, Singer, Christian F., Colomer, Ramón, Benhamú, Bellinda, López-Rodríguez, María Luz, Valent, Peter, Grunt, Thomas W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355289/ https://www.ncbi.nlm.nih.gov/pubmed/28086243 http://dx.doi.org/10.18632/oncotarget.14591

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