Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal

The aim of this study was to investigate the protective effects of matrine on lipopolysaccharide (LPS)-induced inflammation and oxidative stress in vivo and in vitro. The results showed that matrine improved intestinal inflammatory status and oxidative balance and enhanced chemokine receptor 7 (CCR7...

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Detalles Bibliográficos
Autores principales: Wu, Guojun, Zhou, Wenhong, Zhao, Junfeng, Pan, Xiaohua, Sun, Yongjie, Xu, Hao, Shi, Peng, Geng, Chong, Gao, Ling, Tian, Xingsong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355291/
https://www.ncbi.nlm.nih.gov/pubmed/28086227
http://dx.doi.org/10.18632/oncotarget.14598
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author Wu, Guojun
Zhou, Wenhong
Zhao, Junfeng
Pan, Xiaohua
Sun, Yongjie
Xu, Hao
Shi, Peng
Geng, Chong
Gao, Ling
Tian, Xingsong
author_facet Wu, Guojun
Zhou, Wenhong
Zhao, Junfeng
Pan, Xiaohua
Sun, Yongjie
Xu, Hao
Shi, Peng
Geng, Chong
Gao, Ling
Tian, Xingsong
author_sort Wu, Guojun
collection PubMed
description The aim of this study was to investigate the protective effects of matrine on lipopolysaccharide (LPS)-induced inflammation and oxidative stress in vivo and in vitro. The results showed that matrine improved intestinal inflammatory status and oxidative balance and enhanced chemokine receptor 7 (CCR7) expression. In LPS-challenged mice and Caco-2 cells, matrine alleviated LPS-induced inflammation and oxidative stress via downregulating pro-inflammatory cytokines (IL-1β and IL-17) and malondialdehyde (MDA) production. CCR7-siRNA transfection blocked the protective effects of matrine on LPS-induced inflammation and oxidative stress and exacerbated LPS caused injury. In conclusion, matrine alleviates LPS-induced intestinal inflammation and oxidative stress in mice and Caco-2 cells, which may be associated with CCR7 signal.
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spelling pubmed-53552912017-04-26 Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal Wu, Guojun Zhou, Wenhong Zhao, Junfeng Pan, Xiaohua Sun, Yongjie Xu, Hao Shi, Peng Geng, Chong Gao, Ling Tian, Xingsong Oncotarget Research Paper The aim of this study was to investigate the protective effects of matrine on lipopolysaccharide (LPS)-induced inflammation and oxidative stress in vivo and in vitro. The results showed that matrine improved intestinal inflammatory status and oxidative balance and enhanced chemokine receptor 7 (CCR7) expression. In LPS-challenged mice and Caco-2 cells, matrine alleviated LPS-induced inflammation and oxidative stress via downregulating pro-inflammatory cytokines (IL-1β and IL-17) and malondialdehyde (MDA) production. CCR7-siRNA transfection blocked the protective effects of matrine on LPS-induced inflammation and oxidative stress and exacerbated LPS caused injury. In conclusion, matrine alleviates LPS-induced intestinal inflammation and oxidative stress in mice and Caco-2 cells, which may be associated with CCR7 signal. Impact Journals LLC 2017-01-11 /pmc/articles/PMC5355291/ /pubmed/28086227 http://dx.doi.org/10.18632/oncotarget.14598 Text en Copyright: © 2017 Wu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wu, Guojun
Zhou, Wenhong
Zhao, Junfeng
Pan, Xiaohua
Sun, Yongjie
Xu, Hao
Shi, Peng
Geng, Chong
Gao, Ling
Tian, Xingsong
Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal
title Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal
title_full Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal
title_fullStr Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal
title_full_unstemmed Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal
title_short Matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via CCR7 signal
title_sort matrine alleviates lipopolysaccharide-induced intestinal inflammation and oxidative stress via ccr7 signal
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355291/
https://www.ncbi.nlm.nih.gov/pubmed/28086227
http://dx.doi.org/10.18632/oncotarget.14598
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