A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines

Cardiac glycosides are well known in the treatment of cardiovascular diseases; however, their application as treatment option for cancer patients is under discussion. We showed that the cardiac glycoside digitoxin and its analog AMANTADIG can inhibit the growth of renal cell carcinoma (RCC) cell lin...

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Detalles Bibliográficos
Autores principales: Nolte, Elke, Wach, Sven, Silva, Izabella Thais, Lukat, Sabine, Ekici, Arif B., Munkert, Jennifer, Müller-Uri, Frieder, Kreis, Wolfgang, Simões, Cláudia Maria Oliveira, Vera, Julio, Wullich, Bernd, Taubert, Helge, Lai, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355295/
https://www.ncbi.nlm.nih.gov/pubmed/28099931
http://dx.doi.org/10.18632/oncotarget.14644

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