Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2

Lung cancer is the leading cause of cancer related death which needs novel drugs to improve patient outcomes. In this study, we examined the ability of YF-18, a novel matrine derivative to inhibit the growth and migration of lung cancer cells. By cell cycle analysis, wound healing and transwell assa...

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Detalles Bibliográficos
Autores principales: Wu, Lichuan, Wang, Guizhen, Wei, Jinrui, Huang, Na, Zhang, Sen, Yang, Fangfang, Li, Ming, Zhou, Guangbiao, Wang, Lisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355299/
https://www.ncbi.nlm.nih.gov/pubmed/28036296
http://dx.doi.org/10.18632/oncotarget.14329
Descripción
Sumario:Lung cancer is the leading cause of cancer related death which needs novel drugs to improve patient outcomes. In this study, we examined the ability of YF-18, a novel matrine derivative to inhibit the growth and migration of lung cancer cells. By cell cycle analysis, wound healing and transwell assays, we found that YF-18 induced G2/M cell cycle arrest and inhibited migration of lung cancer cells in a dose-dependent manner. Further results indicated that YF-18 inhibited cell proliferation and migration through down-regulating Skp2 and up-regulating its substrates, p27 and E-cadherin. Moreover, YF-18 inhibited A549-luciferase cell xenograft tumor growth in a dose-dependent manner. The findings indicate that YF-18 bears therapeutic potentials for lung cancer.

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