Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2

Lung cancer is the leading cause of cancer related death which needs novel drugs to improve patient outcomes. In this study, we examined the ability of YF-18, a novel matrine derivative to inhibit the growth and migration of lung cancer cells. By cell cycle analysis, wound healing and transwell assa...

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Detalles Bibliográficos
Autores principales: Wu, Lichuan, Wang, Guizhen, Wei, Jinrui, Huang, Na, Zhang, Sen, Yang, Fangfang, Li, Ming, Zhou, Guangbiao, Wang, Lisheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355299/
https://www.ncbi.nlm.nih.gov/pubmed/28036296
http://dx.doi.org/10.18632/oncotarget.14329
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author Wu, Lichuan
Wang, Guizhen
Wei, Jinrui
Huang, Na
Zhang, Sen
Yang, Fangfang
Li, Ming
Zhou, Guangbiao
Wang, Lisheng
author_facet Wu, Lichuan
Wang, Guizhen
Wei, Jinrui
Huang, Na
Zhang, Sen
Yang, Fangfang
Li, Ming
Zhou, Guangbiao
Wang, Lisheng
author_sort Wu, Lichuan
collection PubMed
description Lung cancer is the leading cause of cancer related death which needs novel drugs to improve patient outcomes. In this study, we examined the ability of YF-18, a novel matrine derivative to inhibit the growth and migration of lung cancer cells. By cell cycle analysis, wound healing and transwell assays, we found that YF-18 induced G2/M cell cycle arrest and inhibited migration of lung cancer cells in a dose-dependent manner. Further results indicated that YF-18 inhibited cell proliferation and migration through down-regulating Skp2 and up-regulating its substrates, p27 and E-cadherin. Moreover, YF-18 inhibited A549-luciferase cell xenograft tumor growth in a dose-dependent manner. The findings indicate that YF-18 bears therapeutic potentials for lung cancer.
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spelling pubmed-53552992017-04-26 Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2 Wu, Lichuan Wang, Guizhen Wei, Jinrui Huang, Na Zhang, Sen Yang, Fangfang Li, Ming Zhou, Guangbiao Wang, Lisheng Oncotarget Research Paper Lung cancer is the leading cause of cancer related death which needs novel drugs to improve patient outcomes. In this study, we examined the ability of YF-18, a novel matrine derivative to inhibit the growth and migration of lung cancer cells. By cell cycle analysis, wound healing and transwell assays, we found that YF-18 induced G2/M cell cycle arrest and inhibited migration of lung cancer cells in a dose-dependent manner. Further results indicated that YF-18 inhibited cell proliferation and migration through down-regulating Skp2 and up-regulating its substrates, p27 and E-cadherin. Moreover, YF-18 inhibited A549-luciferase cell xenograft tumor growth in a dose-dependent manner. The findings indicate that YF-18 bears therapeutic potentials for lung cancer. Impact Journals LLC 2016-12-28 /pmc/articles/PMC5355299/ /pubmed/28036296 http://dx.doi.org/10.18632/oncotarget.14329 Text en Copyright: © 2017 Wu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wu, Lichuan
Wang, Guizhen
Wei, Jinrui
Huang, Na
Zhang, Sen
Yang, Fangfang
Li, Ming
Zhou, Guangbiao
Wang, Lisheng
Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2
title Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2
title_full Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2
title_fullStr Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2
title_full_unstemmed Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2
title_short Matrine derivative YF-18 inhibits lung cancer cell proliferation and migration through down-regulating Skp2
title_sort matrine derivative yf-18 inhibits lung cancer cell proliferation and migration through down-regulating skp2
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355299/
https://www.ncbi.nlm.nih.gov/pubmed/28036296
http://dx.doi.org/10.18632/oncotarget.14329
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