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Evolutionary selected Tibetan variants of HIF pathway and risk of lung cancer

Tibetans existed in high altitude for ~25 thousand years and have evolutionary selected unique haplotypes assumed to be beneficial to hypoxic adaptation. EGLN1/PHD2 and EPAS1/HIF-2α, both crucial components of hypoxia sensing, are the two best-established loci contributing to high altitude adaptatio...

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Detalles Bibliográficos
Autores principales:	Lanikova, Lucie, Scott Reading, N., Hu, Hao, Tashi, Tsewang, Burjanivova, Tatiana, Shestakova, Anna, Siwakoti, Bhola, Thakur, Binay Kumar, Pun, Chin Bahadur, Sapkota, Amir, Abdelaziz, Sarah, Feng, Bing-Jian, Huff, Chad D., Hashibe, Mia, Prchal, Josef T.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355300/ https://www.ncbi.nlm.nih.gov/pubmed/28036300 http://dx.doi.org/10.18632/oncotarget.14340

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