Autocrine VEGF signaling promotes cell proliferation through a PLC-dependent pathway and modulates Apatinib treatment efficacy in gastric cancer

BACKGROUND: Tumor cells produce vascular endothelial growth factor (VEGF) which interact with the membrane or cytoplasmic VEGF receptors (VEGFRs) to promote cell growth in an angiogenesis-independent fashion. Apatinib, a highly selective VEGFR2 inhibitor, is the only effective drug for patients with...

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Detalles Bibliográficos
Autores principales: Lin, Yi, Zhai, Ertao, Liao, Bing, Xu, Lixia, Zhang, Xinhua, Peng, Sui, He, Yulong, Cai, Shirong, Zeng, Zhirong, Chen, Minhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355320/
https://www.ncbi.nlm.nih.gov/pubmed/28061477
http://dx.doi.org/10.18632/oncotarget.14467

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