Molecular dynamics simulation reveals how phosphorylation of tyrosine 26 of phosphoglycerate mutase 1 upregulates glycolysis and promotes tumor growth

Phosphoglycerate mutase 1 (PGAM1) catalyzes the eighth step of glycolysis and is often found upregulated in cancer cells. To test the hypothesis that the phosphorylation of tyrosine 26 residue of PGAM1 greatly enhances its activity, we performed both conventional and steered molecular dynamics simul...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Yan, Cai, Wen-Sheng, Chen, Luonan, Wang, Guanyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355328/
https://www.ncbi.nlm.nih.gov/pubmed/28076845
http://dx.doi.org/10.18632/oncotarget.14517

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355328/
https://www.ncbi.nlm.nih.gov/pubmed/28076845
http://dx.doi.org/10.18632/oncotarget.14517

Ejemplares similares