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Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer
Background and aim: High levels of peripheral plasma fibrinogen have recently been revealed that related to poor clinical prognosis in various types of malignant tumors. The purpose of this research was to identify the prognostic significance of the preoperative peripheral serum fibrinogen level in...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355350/ https://www.ncbi.nlm.nih.gov/pubmed/27738342 http://dx.doi.org/10.18632/oncotarget.12563 |
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author | Ma, Chengquan Zhou, Yaguang Zhou, Sufen Zhao, Kun Lu, Bingxin Sun, Erlin |
author_facet | Ma, Chengquan Zhou, Yaguang Zhou, Sufen Zhao, Kun Lu, Bingxin Sun, Erlin |
author_sort | Ma, Chengquan |
collection | PubMed |
description | Background and aim: High levels of peripheral plasma fibrinogen have recently been revealed that related to poor clinical prognosis in various types of malignant tumors. The purpose of this research was to identify the prognostic significance of the preoperative peripheral serum fibrinogen level in patients with penile cell carcinoma. Methods: This retrospective research included 72 penile cancer patients with date about their serum fibrinogen value before surgery who undergone either partial or radical penectomy at The 2nd Hospital of Tianjin Medical University between January 2002 to January 2012. They had a mean follow-up of 30.8 months. To determine the factors that were significant in predicting a patients prognosis, univariate and multivariate analyses were performed according to the Cox proportional hazards regression model. Results: The 5-year cancer specific survival (CSS) rate was 62.4% of patients with preoperative fibrinogen levels below 340 mg/dl and 41.9% for those with higher levels (p = 0.001). Multivariate analysis revealed that the pathological T stage (p < 0.001), tumor grade (p = 0.036), postoperative chemotherapy (p = 0.041), nodal metastasis(p < 0.001), pathological type (p < 0.001) and fibrinogen (p = 0.023) were independent prognostic factors for survival. Patients with low fibrinogen level (<340mg/dl) had significantly longer CSS and the different survival rate were defined using the log-rank test. Conclusions: The high preoperative peripheral serum fibrinogen level was related to poor survival in penile cancer patients. Fibrinogen may serve as a powerful predictor of CSS in penile cancer patients. |
format | Online Article Text |
id | pubmed-5355350 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53553502017-04-26 Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer Ma, Chengquan Zhou, Yaguang Zhou, Sufen Zhao, Kun Lu, Bingxin Sun, Erlin Oncotarget Clinical Research Paper Background and aim: High levels of peripheral plasma fibrinogen have recently been revealed that related to poor clinical prognosis in various types of malignant tumors. The purpose of this research was to identify the prognostic significance of the preoperative peripheral serum fibrinogen level in patients with penile cell carcinoma. Methods: This retrospective research included 72 penile cancer patients with date about their serum fibrinogen value before surgery who undergone either partial or radical penectomy at The 2nd Hospital of Tianjin Medical University between January 2002 to January 2012. They had a mean follow-up of 30.8 months. To determine the factors that were significant in predicting a patients prognosis, univariate and multivariate analyses were performed according to the Cox proportional hazards regression model. Results: The 5-year cancer specific survival (CSS) rate was 62.4% of patients with preoperative fibrinogen levels below 340 mg/dl and 41.9% for those with higher levels (p = 0.001). Multivariate analysis revealed that the pathological T stage (p < 0.001), tumor grade (p = 0.036), postoperative chemotherapy (p = 0.041), nodal metastasis(p < 0.001), pathological type (p < 0.001) and fibrinogen (p = 0.023) were independent prognostic factors for survival. Patients with low fibrinogen level (<340mg/dl) had significantly longer CSS and the different survival rate were defined using the log-rank test. Conclusions: The high preoperative peripheral serum fibrinogen level was related to poor survival in penile cancer patients. Fibrinogen may serve as a powerful predictor of CSS in penile cancer patients. Impact Journals LLC 2016-10-11 /pmc/articles/PMC5355350/ /pubmed/27738342 http://dx.doi.org/10.18632/oncotarget.12563 Text en Copyright: © 2017 Ma et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Clinical Research Paper Ma, Chengquan Zhou, Yaguang Zhou, Sufen Zhao, Kun Lu, Bingxin Sun, Erlin Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer |
title | Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer |
title_full | Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer |
title_fullStr | Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer |
title_full_unstemmed | Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer |
title_short | Preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer |
title_sort | preoperative peripheral plasma fibrinogen level is an independent prognostic marker in penile cancer |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355350/ https://www.ncbi.nlm.nih.gov/pubmed/27738342 http://dx.doi.org/10.18632/oncotarget.12563 |
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