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MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers
Evidence has shown that microRNAs are widely implicated as indispensable components of tumor suppressive and oncogenic pathways in human cancers. Thus, identification of microRNA targets and their relevant pathways will contribute to the development of microRNA-based therapeutics. The forkhead box t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355356/ https://www.ncbi.nlm.nih.gov/pubmed/27999212 http://dx.doi.org/10.18632/oncotarget.14015 |
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author | Li, Chen Zhang, Kai Chen, Jing Chen, Longbang Wang, Rui Chu, Xiaoyuan |
author_facet | Li, Chen Zhang, Kai Chen, Jing Chen, Longbang Wang, Rui Chu, Xiaoyuan |
author_sort | Li, Chen |
collection | PubMed |
description | Evidence has shown that microRNAs are widely implicated as indispensable components of tumor suppressive and oncogenic pathways in human cancers. Thus, identification of microRNA targets and their relevant pathways will contribute to the development of microRNA-based therapeutics. The forkhead box transcription factors regulate numerous processes including cell cycle progression, metabolism, metastasis and angiogenesis, thereby facilitating tumor initiation and progression. A complex network of protein and non-coding RNAs mediates the expression and activity of forkhead box transcription factors. In this review, we summarize the current knowledge and concepts concerning the involvement of microRNAs and forkhead box transcription factors and describe the roles of microRNAs-forkhead box axis in various disease states including tumor initiation and progression. Additionally, we describe some of the technical challenges in the use of the microRNA-forkhead box signaling pathway in cancer treatment. |
format | Online Article Text |
id | pubmed-5355356 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53553562017-04-26 MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers Li, Chen Zhang, Kai Chen, Jing Chen, Longbang Wang, Rui Chu, Xiaoyuan Oncotarget Review Evidence has shown that microRNAs are widely implicated as indispensable components of tumor suppressive and oncogenic pathways in human cancers. Thus, identification of microRNA targets and their relevant pathways will contribute to the development of microRNA-based therapeutics. The forkhead box transcription factors regulate numerous processes including cell cycle progression, metabolism, metastasis and angiogenesis, thereby facilitating tumor initiation and progression. A complex network of protein and non-coding RNAs mediates the expression and activity of forkhead box transcription factors. In this review, we summarize the current knowledge and concepts concerning the involvement of microRNAs and forkhead box transcription factors and describe the roles of microRNAs-forkhead box axis in various disease states including tumor initiation and progression. Additionally, we describe some of the technical challenges in the use of the microRNA-forkhead box signaling pathway in cancer treatment. Impact Journals LLC 2016-12-16 /pmc/articles/PMC5355356/ /pubmed/27999212 http://dx.doi.org/10.18632/oncotarget.14015 Text en Copyright: © 2017 Li et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Li, Chen Zhang, Kai Chen, Jing Chen, Longbang Wang, Rui Chu, Xiaoyuan MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers |
title | MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers |
title_full | MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers |
title_fullStr | MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers |
title_full_unstemmed | MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers |
title_short | MicroRNAs as regulators and mediators of forkhead box transcription factors function in human cancers |
title_sort | micrornas as regulators and mediators of forkhead box transcription factors function in human cancers |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355356/ https://www.ncbi.nlm.nih.gov/pubmed/27999212 http://dx.doi.org/10.18632/oncotarget.14015 |
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