The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity

Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene regulation and encompass the well-known microRNAs (miRNAs), as well as the most recently acknowledged long noncoding RNAs (lncRNAs). Current evidence indicates that lncRNAs can interact with miRNAs and these interactions p...

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Autores principales: Cao, Ming-xin, Jiang, Ya-ping, Tang, Ya-ling, Liang, Xin-hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355358/
https://www.ncbi.nlm.nih.gov/pubmed/27992370
http://dx.doi.org/10.18632/oncotarget.13957
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author Cao, Ming-xin
Jiang, Ya-ping
Tang, Ya-ling
Liang, Xin-hua
author_facet Cao, Ming-xin
Jiang, Ya-ping
Tang, Ya-ling
Liang, Xin-hua
author_sort Cao, Ming-xin
collection PubMed
description Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene regulation and encompass the well-known microRNAs (miRNAs), as well as the most recently acknowledged long noncoding RNAs (lncRNAs). Current evidence indicates that lncRNAs can interact with miRNAs and these interactions play crucial roles in cancer metastasis, through regulating critical events especially the epithelial-mesenchymal transition (EMT). This review summarizes the types of lncRNA-miRNA crosstalk identified to-date and discusses their influence on the epithelial-mesenchymal plasticity and clinical metastatic implication.
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spelling pubmed-53553582017-04-26 The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity Cao, Ming-xin Jiang, Ya-ping Tang, Ya-ling Liang, Xin-hua Oncotarget Review Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene regulation and encompass the well-known microRNAs (miRNAs), as well as the most recently acknowledged long noncoding RNAs (lncRNAs). Current evidence indicates that lncRNAs can interact with miRNAs and these interactions play crucial roles in cancer metastasis, through regulating critical events especially the epithelial-mesenchymal transition (EMT). This review summarizes the types of lncRNA-miRNA crosstalk identified to-date and discusses their influence on the epithelial-mesenchymal plasticity and clinical metastatic implication. Impact Journals LLC 2016-12-15 /pmc/articles/PMC5355358/ /pubmed/27992370 http://dx.doi.org/10.18632/oncotarget.13957 Text en Copyright: © 2017 Cao et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Review
Cao, Ming-xin
Jiang, Ya-ping
Tang, Ya-ling
Liang, Xin-hua
The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity
title The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity
title_full The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity
title_fullStr The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity
title_full_unstemmed The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity
title_short The crosstalk between lncRNA and microRNA in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity
title_sort crosstalk between lncrna and microrna in cancer metastasis: orchestrating the epithelial-mesenchymal plasticity
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355358/
https://www.ncbi.nlm.nih.gov/pubmed/27992370
http://dx.doi.org/10.18632/oncotarget.13957
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