Obesity-Induced Metabolic Stress Leads to Biased Effector Memory CD4(+) T Cell Differentiation via PI3K p110δ-Akt-Mediated Signals

Low-grade systemic inflammation associated to obesity leads to cardiovascular complications, caused partly by infiltration of adipose and vascular tissue by effector T cells. The signals leading to T cell differentiation and tissue infiltration during obesity are poorly understood. We tested whether...

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Detalles Bibliográficos
Autores principales: Mauro, Claudio, Smith, Joanne, Cucchi, Danilo, Coe, David, Fu, Hongmei, Bonacina, Fabrizia, Baragetti, Andrea, Cermenati, Gaia, Caruso, Donatella, Mitro, Nico, Catapano, Alberico L., Ammirati, Enrico, Longhi, Maria P., Okkenhaug, Klaus, Norata, Giuseppe D., Marelli-Berg, Federica M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355363/
https://www.ncbi.nlm.nih.gov/pubmed/28190771
http://dx.doi.org/10.1016/j.cmet.2017.01.008

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