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Calcitonin gene-related peptide and pain: a systematic review
BACKGROUND: Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in migraine pathophysiology but its role in non-headache pain has not been clarified...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer Milan
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355411/ https://www.ncbi.nlm.nih.gov/pubmed/28303458 http://dx.doi.org/10.1186/s10194-017-0741-2 |
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author | Schou, Wendy Sophie Ashina, Sait Amin, Faisal Mohammad Goadsby, Peter J. Ashina, Messoud |
author_facet | Schou, Wendy Sophie Ashina, Sait Amin, Faisal Mohammad Goadsby, Peter J. Ashina, Messoud |
author_sort | Schou, Wendy Sophie |
collection | PubMed |
description | BACKGROUND: Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in migraine pathophysiology but its role in non-headache pain has not been clarified. METHODS: We performed a systematic literature search on PubMed, Embase and ClinicalTrials.gov for articles on CGRP and non-headache pain covering human studies including experimental studies and randomized clinical trials. RESULTS: The literature search identified 375 citations of which 50 contained relevant original data. An association between measured CGRP levels and somatic, visceral, neuropathic and inflammatory pain was found. In 13 out of 20 studies in somatic pain conditions, CGRP levels had a positive correlation with pain. Increased CGRP levels were reported in plasma, synovial and cerebrospinal fluid in subjects with musculoskeletal pain. A randomized clinical trial on monoclonal antibody, which selectively binds to and inhibits the activity of CGRP (galcanezumab) in patients with osteoarthritis knee pain, failed to demonstrate improvement of pain compared with placebo. No studies to date have investigated the efficacy of monoclonal antibodies against CGRP receptor in non-headache pain conditions. CONCLUSION: The present review revealed the association between measured CGRP levels and somatic, visceral, neuropathic and inflammatory pain. These data suggest that CGRP may act as a neuromodulator in non-headache pain conditions. However, more studies are needed to fully understand the role of CGRP in nociceptive processing and therapy of chronic pain. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s10194-017-0741-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-5355411 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Milan |
record_format | MEDLINE/PubMed |
spelling | pubmed-53554112017-03-30 Calcitonin gene-related peptide and pain: a systematic review Schou, Wendy Sophie Ashina, Sait Amin, Faisal Mohammad Goadsby, Peter J. Ashina, Messoud J Headache Pain Research Article BACKGROUND: Calcitonin gene-related peptide (CGRP) is widely distributed in nociceptive pathways in human peripheral and central nervous system and its receptors are also expressed in pain pathways. CGRP is involved in migraine pathophysiology but its role in non-headache pain has not been clarified. METHODS: We performed a systematic literature search on PubMed, Embase and ClinicalTrials.gov for articles on CGRP and non-headache pain covering human studies including experimental studies and randomized clinical trials. RESULTS: The literature search identified 375 citations of which 50 contained relevant original data. An association between measured CGRP levels and somatic, visceral, neuropathic and inflammatory pain was found. In 13 out of 20 studies in somatic pain conditions, CGRP levels had a positive correlation with pain. Increased CGRP levels were reported in plasma, synovial and cerebrospinal fluid in subjects with musculoskeletal pain. A randomized clinical trial on monoclonal antibody, which selectively binds to and inhibits the activity of CGRP (galcanezumab) in patients with osteoarthritis knee pain, failed to demonstrate improvement of pain compared with placebo. No studies to date have investigated the efficacy of monoclonal antibodies against CGRP receptor in non-headache pain conditions. CONCLUSION: The present review revealed the association between measured CGRP levels and somatic, visceral, neuropathic and inflammatory pain. These data suggest that CGRP may act as a neuromodulator in non-headache pain conditions. However, more studies are needed to fully understand the role of CGRP in nociceptive processing and therapy of chronic pain. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (doi:10.1186/s10194-017-0741-2) contains supplementary material, which is available to authorized users. Springer Milan 2017-03-16 /pmc/articles/PMC5355411/ /pubmed/28303458 http://dx.doi.org/10.1186/s10194-017-0741-2 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Research Article Schou, Wendy Sophie Ashina, Sait Amin, Faisal Mohammad Goadsby, Peter J. Ashina, Messoud Calcitonin gene-related peptide and pain: a systematic review |
title | Calcitonin gene-related peptide and pain: a systematic review |
title_full | Calcitonin gene-related peptide and pain: a systematic review |
title_fullStr | Calcitonin gene-related peptide and pain: a systematic review |
title_full_unstemmed | Calcitonin gene-related peptide and pain: a systematic review |
title_short | Calcitonin gene-related peptide and pain: a systematic review |
title_sort | calcitonin gene-related peptide and pain: a systematic review |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355411/ https://www.ncbi.nlm.nih.gov/pubmed/28303458 http://dx.doi.org/10.1186/s10194-017-0741-2 |
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