Combined antitumor activity of the nitroreductase/CB1954 suicide gene system and γ-rays in HeLa cells in vitro

Escherichia coli nitroreductase (NTR) may convert the prodrug CB1954 (5-(aziridin-1-yl)-2,4-dinitrobenzamide) into a bifunctional alkylating agent, which may lead to DNA crosslinks and the apoptosis of cancer cells. NTR/CB1954 has been demonstrated to be an effective gene therapy in cancer cells. Th...

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Detalles Bibliográficos
Autores principales: Teng, Geling, Ju, Yuanrong, Yang, Yepeng, Hua, Hu, Chi, Jingyu, Mu, Xiuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355654/
https://www.ncbi.nlm.nih.gov/pubmed/27840931
http://dx.doi.org/10.3892/mmr.2016.5917

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355654/
https://www.ncbi.nlm.nih.gov/pubmed/27840931
http://dx.doi.org/10.3892/mmr.2016.5917

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