NLS-RARα modulates acute promyelocytic leukemia NB4 cell proliferation and differentiation via the PI3K/AKT pathway

In patients with acute promyelocytic leukemia (APL), ~98% express the promyelocytic leukemia (PML)-retinoic acid receptor α (RARα) fusion protein. Previous studies have shown that, in primary leukemia cells of patients with APL, the cleavage of PML-RARα by neutrophil elastase is important for its ab...

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Detalles Bibliográficos
Autores principales: Song, Hao, Li, Liu, Zhong, Liang, Yang, Rong, Jiang, Kailing, Yang, Xiaoqun, Liu, Beizhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2016
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355661/
https://www.ncbi.nlm.nih.gov/pubmed/27840989
http://dx.doi.org/10.3892/mmr.2016.5932

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355661/
https://www.ncbi.nlm.nih.gov/pubmed/27840989
http://dx.doi.org/10.3892/mmr.2016.5932

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