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Degradation of P-glycoprotein by pristimerin contributes to overcoming ABCB1-mediated chemotherapeutic drug resistance in vitro

ABCB1 (P-glycoprotein, ABCB1/MDR1) is one of the major members of the ABC transporters linked to MDR in cancer cells. In this study, we observed that pristimerin, a natural triterpenoid, potently decreased P-gp in a dose-dependent manner in both drug-resistant KBv200 and stable transfected HEK293/AB...

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Detalles Bibliográficos
Autores principales:	Yan, Yan-Yan, Wang, Fang, Zhao, Xiao-Qin, Wang, Xiao-Kun, Chen, Yi-Fan, Liu, Hong, Xie, Yong, Fu, Li-Wu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355671/ https://www.ncbi.nlm.nih.gov/pubmed/27840996 http://dx.doi.org/10.3892/or.2016.5230

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