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SirT1 activator represses the transcription of TNF-α in THP-1 cells of a sepsis model via deacetylation of H4K16

Sepsis is a systemic inflammatory response resulting from the excessive production of pro-inflammatory cytokines, including tumor necrosis factor (TNF)-α. Sirtuin 1 (SirT1) actively deacetylates histone proteins, and facilitates chromatin compaction and gene silencing. In the present study, a cell m...

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Detalles Bibliográficos
Autores principales:	Chen, Guo-Dong, Yu, Wei-Dong, Chen, Xiao-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	D.A. Spandidos 2016
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355689/ https://www.ncbi.nlm.nih.gov/pubmed/27878240 http://dx.doi.org/10.3892/mmr.2016.5942

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