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Total chemical synthesis of proteins without HPLC purification

The total chemical synthesis of proteins is a tedious and time-consuming endeavour. The typical steps involve solid phase synthesis of peptide thioesters and cysteinyl peptides, native chemical ligation (NCL) in solution, desulfurization or removal of ligation auxiliaries in the case of extended NCL...

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Detalles Bibliográficos
Autores principales:	Loibl, S. F., Harpaz, Z., Zitterbart, R., Seitz, O.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2016
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355786/ https://www.ncbi.nlm.nih.gov/pubmed/28451120 http://dx.doi.org/10.1039/c6sc01883a

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