Palladium-catalysed synthesis of triaryl(heteroaryl)methanes

Tetraarylmethane derivatives are desirable for a variety of applications, but difficult to access with modern C–C bond-forming reactions. Here we report a straightforward method for palladium-catalysed arylation of aryl(heteroaryl)methanes and diaryl(heteroaryl)methanes with aryl chlorides. This rea...

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Autores principales: Zhang, Shuguang, Kim, Byeong-Seon, Wu, Chen, Mao, Jianyou, Walsh, Patrick J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355892/
https://www.ncbi.nlm.nih.gov/pubmed/28290445
http://dx.doi.org/10.1038/ncomms14641
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author Zhang, Shuguang
Kim, Byeong-Seon
Wu, Chen
Mao, Jianyou
Walsh, Patrick J.
author_facet Zhang, Shuguang
Kim, Byeong-Seon
Wu, Chen
Mao, Jianyou
Walsh, Patrick J.
author_sort Zhang, Shuguang
collection PubMed
description Tetraarylmethane derivatives are desirable for a variety of applications, but difficult to access with modern C–C bond-forming reactions. Here we report a straightforward method for palladium-catalysed arylation of aryl(heteroaryl)methanes and diaryl(heteroaryl)methanes with aryl chlorides. This reaction enables introduction of various aryl groups to construct triaryl(heteroaryl)methanes via a C–H functionalization in good to excellent yield, and represents the first step towards a general transition metal catalysed synthesis of tetraarylmethanes.
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spelling pubmed-53558922017-04-17 Palladium-catalysed synthesis of triaryl(heteroaryl)methanes Zhang, Shuguang Kim, Byeong-Seon Wu, Chen Mao, Jianyou Walsh, Patrick J. Nat Commun Article Tetraarylmethane derivatives are desirable for a variety of applications, but difficult to access with modern C–C bond-forming reactions. Here we report a straightforward method for palladium-catalysed arylation of aryl(heteroaryl)methanes and diaryl(heteroaryl)methanes with aryl chlorides. This reaction enables introduction of various aryl groups to construct triaryl(heteroaryl)methanes via a C–H functionalization in good to excellent yield, and represents the first step towards a general transition metal catalysed synthesis of tetraarylmethanes. Nature Publishing Group 2017-03-14 /pmc/articles/PMC5355892/ /pubmed/28290445 http://dx.doi.org/10.1038/ncomms14641 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Zhang, Shuguang
Kim, Byeong-Seon
Wu, Chen
Mao, Jianyou
Walsh, Patrick J.
Palladium-catalysed synthesis of triaryl(heteroaryl)methanes
title Palladium-catalysed synthesis of triaryl(heteroaryl)methanes
title_full Palladium-catalysed synthesis of triaryl(heteroaryl)methanes
title_fullStr Palladium-catalysed synthesis of triaryl(heteroaryl)methanes
title_full_unstemmed Palladium-catalysed synthesis of triaryl(heteroaryl)methanes
title_short Palladium-catalysed synthesis of triaryl(heteroaryl)methanes
title_sort palladium-catalysed synthesis of triaryl(heteroaryl)methanes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355892/
https://www.ncbi.nlm.nih.gov/pubmed/28290445
http://dx.doi.org/10.1038/ncomms14641
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AT maojianyou palladiumcatalysedsynthesisoftriarylheteroarylmethanes
AT walshpatrickj palladiumcatalysedsynthesisoftriarylheteroarylmethanes

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