Oxidative DNA damage induces hypomethylation in a compromised base excision repair colorectal tumourigenesis

BACKGROUND: A compromised base excision repair (BER) promotes carcinogenesis by accumulating oxidative DNA-damaged products as observed in MUTYH-associated polyposis, a hereditary colorectal cancer syndrome marked by adenomas and cancers with an accumulation of 8-oxoguanine. Remarkably, DNA global d...

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Detalles Bibliográficos
Autores principales: Furlan, Daniela, Trapani, Davide, Berrino, Enrico, Debernardi, Carla, Panero, Mara, Libera, Laura, Sahnane, Nora, Riva, Cristina, Tibiletti, Maria Grazia, Sessa, Fausto, Sapino, Anna, Venesio, Tiziana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Genetics & Genomics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355935/
https://www.ncbi.nlm.nih.gov/pubmed/28141798
http://dx.doi.org/10.1038/bjc.2017.9

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