Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion

The Rab GTPase effector, Rab-coupling protein (RCP) is known to promote invasive behaviour in vitro by controlling integrin and receptor tyrosine kinase (RTK) trafficking, but how RCP influences metastasis in vivo is unclear. Here we identify an RTK of the Eph family, EphA2, to be a cargo of an RCP-...

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Detalles Bibliográficos
Autores principales: Gundry, Christine, Marco, Sergi, Rainero, Elena, Miller, Bryan, Dornier, Emmanuel, Mitchell, Louise, Caswell, Patrick T., Campbell, Andrew D., Hogeweg, Anna, Sansom, Owen J., Morton, Jennifer P., Norman, Jim C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355957/
https://www.ncbi.nlm.nih.gov/pubmed/28294115
http://dx.doi.org/10.1038/ncomms14646

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