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Reduced Regional Grey Matter Volumes in Pediatric Obstructive Sleep Apnea
Pediatric OSA is associated with cognitive risk. Since adult OSA manifests MRI evidence of brain injury, and animal models lead to regional neuronal losses, pediatric OSA patients may also be affected. We assessed the presence of neuronal injury, measured as regional grey matter volume, in 16 OSA ch...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355989/ https://www.ncbi.nlm.nih.gov/pubmed/28303917 http://dx.doi.org/10.1038/srep44566 |
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author | Philby, Mona F. Macey, Paul M. Ma, Richard A. Kumar, Rajesh Gozal, David Kheirandish-Gozal, Leila |
author_facet | Philby, Mona F. Macey, Paul M. Ma, Richard A. Kumar, Rajesh Gozal, David Kheirandish-Gozal, Leila |
author_sort | Philby, Mona F. |
collection | PubMed |
description | Pediatric OSA is associated with cognitive risk. Since adult OSA manifests MRI evidence of brain injury, and animal models lead to regional neuronal losses, pediatric OSA patients may also be affected. We assessed the presence of neuronal injury, measured as regional grey matter volume, in 16 OSA children (8 male, 8.1 ± 2.2 years, AHI:11.1 ± 5.9 events/hr), and 200 control subjects (84 male, 8.2 ± 2.0 years), 191 of whom were from the NIH-Pediatric MRI database. High resolution T1-weighted whole-brain images were assessed between groups with voxel-based morphometry, using ANCOVA (covariates, age and gender; family-wise error correction, P < 0.01). Significant grey matter volume reductions appeared in OSA throughout areas of the superior frontal and prefrontal, and superior and lateral parietal cortices. Other affected sites included the brainstem, ventral medial prefrontal cortex, and superior temporal lobe, mostly on the left side. Thus, pediatric OSA subjects show extensive regionally-demarcated grey matter volume reductions in areas that control cognition and mood functions, even if such losses are apparently independent of cognitive deficits. Since OSA disease duration in our subjects is unknown, these findings may result from either delayed neuronal development, neuronal damaging processes, or a combination thereof, and could either reflect neuronal atrophy or reductions in cellular volume (neurons and glia). |
format | Online Article Text |
id | pubmed-5355989 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53559892017-03-22 Reduced Regional Grey Matter Volumes in Pediatric Obstructive Sleep Apnea Philby, Mona F. Macey, Paul M. Ma, Richard A. Kumar, Rajesh Gozal, David Kheirandish-Gozal, Leila Sci Rep Article Pediatric OSA is associated with cognitive risk. Since adult OSA manifests MRI evidence of brain injury, and animal models lead to regional neuronal losses, pediatric OSA patients may also be affected. We assessed the presence of neuronal injury, measured as regional grey matter volume, in 16 OSA children (8 male, 8.1 ± 2.2 years, AHI:11.1 ± 5.9 events/hr), and 200 control subjects (84 male, 8.2 ± 2.0 years), 191 of whom were from the NIH-Pediatric MRI database. High resolution T1-weighted whole-brain images were assessed between groups with voxel-based morphometry, using ANCOVA (covariates, age and gender; family-wise error correction, P < 0.01). Significant grey matter volume reductions appeared in OSA throughout areas of the superior frontal and prefrontal, and superior and lateral parietal cortices. Other affected sites included the brainstem, ventral medial prefrontal cortex, and superior temporal lobe, mostly on the left side. Thus, pediatric OSA subjects show extensive regionally-demarcated grey matter volume reductions in areas that control cognition and mood functions, even if such losses are apparently independent of cognitive deficits. Since OSA disease duration in our subjects is unknown, these findings may result from either delayed neuronal development, neuronal damaging processes, or a combination thereof, and could either reflect neuronal atrophy or reductions in cellular volume (neurons and glia). Nature Publishing Group 2017-03-17 /pmc/articles/PMC5355989/ /pubmed/28303917 http://dx.doi.org/10.1038/srep44566 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Philby, Mona F. Macey, Paul M. Ma, Richard A. Kumar, Rajesh Gozal, David Kheirandish-Gozal, Leila Reduced Regional Grey Matter Volumes in Pediatric Obstructive Sleep Apnea |
title | Reduced Regional Grey Matter Volumes in Pediatric Obstructive Sleep Apnea |
title_full | Reduced Regional Grey Matter Volumes in Pediatric Obstructive Sleep Apnea |
title_fullStr | Reduced Regional Grey Matter Volumes in Pediatric Obstructive Sleep Apnea |
title_full_unstemmed | Reduced Regional Grey Matter Volumes in Pediatric Obstructive Sleep Apnea |
title_short | Reduced Regional Grey Matter Volumes in Pediatric Obstructive Sleep Apnea |
title_sort | reduced regional grey matter volumes in pediatric obstructive sleep apnea |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355989/ https://www.ncbi.nlm.nih.gov/pubmed/28303917 http://dx.doi.org/10.1038/srep44566 |
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