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Altered microstructure rather than morphology in the corpus callosum after lower limb amputation
The corpus callosum (CC) has been implicated in the reorganization of the brain following amputation. However, it is unclear which regions of the CC are involved in this process. In this study, we explored the morphometric and microstructural changes in CC subregions in patients with unilateral lowe...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355997/ https://www.ncbi.nlm.nih.gov/pubmed/28303959 http://dx.doi.org/10.1038/srep44780 |
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author | Li, Zhichao Li, Chuanming Fan, Lingzhong Jiang, Guangyao Wu, Jixiang Jiang, Tianzi Yin, Xuntao Wang, Jian |
author_facet | Li, Zhichao Li, Chuanming Fan, Lingzhong Jiang, Guangyao Wu, Jixiang Jiang, Tianzi Yin, Xuntao Wang, Jian |
author_sort | Li, Zhichao |
collection | PubMed |
description | The corpus callosum (CC) has been implicated in the reorganization of the brain following amputation. However, it is unclear which regions of the CC are involved in this process. In this study, we explored the morphometric and microstructural changes in CC subregions in patients with unilateral lower limb amputation. Thirty-eight patients and 38 age- and gender-matched normal controls were included. The CC was divided into five regions, and the area, thickness and diffusion parameters of each region were investigated. While morphometric analysis showed no significant differences between the two groups, amputees showed significant higher values in axial diffusivity, radial diffusivity and mean diffusivity in region II of the CC, which connects the bilateral premotor and supplementary motor areas. In contrast, the mean fractional anisotropy value of the fibers generated by these cortical areas, as measured by tractography, was significantly smaller in amputees. These results demonstrate that the interhemispheric pathways contributing to motor coordination and imagery are reorganized in lower limb amputees. |
format | Online Article Text |
id | pubmed-5355997 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-53559972017-03-22 Altered microstructure rather than morphology in the corpus callosum after lower limb amputation Li, Zhichao Li, Chuanming Fan, Lingzhong Jiang, Guangyao Wu, Jixiang Jiang, Tianzi Yin, Xuntao Wang, Jian Sci Rep Article The corpus callosum (CC) has been implicated in the reorganization of the brain following amputation. However, it is unclear which regions of the CC are involved in this process. In this study, we explored the morphometric and microstructural changes in CC subregions in patients with unilateral lower limb amputation. Thirty-eight patients and 38 age- and gender-matched normal controls were included. The CC was divided into five regions, and the area, thickness and diffusion parameters of each region were investigated. While morphometric analysis showed no significant differences between the two groups, amputees showed significant higher values in axial diffusivity, radial diffusivity and mean diffusivity in region II of the CC, which connects the bilateral premotor and supplementary motor areas. In contrast, the mean fractional anisotropy value of the fibers generated by these cortical areas, as measured by tractography, was significantly smaller in amputees. These results demonstrate that the interhemispheric pathways contributing to motor coordination and imagery are reorganized in lower limb amputees. Nature Publishing Group 2017-03-17 /pmc/articles/PMC5355997/ /pubmed/28303959 http://dx.doi.org/10.1038/srep44780 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Li, Zhichao Li, Chuanming Fan, Lingzhong Jiang, Guangyao Wu, Jixiang Jiang, Tianzi Yin, Xuntao Wang, Jian Altered microstructure rather than morphology in the corpus callosum after lower limb amputation |
title | Altered microstructure rather than morphology in the corpus callosum after lower limb amputation |
title_full | Altered microstructure rather than morphology in the corpus callosum after lower limb amputation |
title_fullStr | Altered microstructure rather than morphology in the corpus callosum after lower limb amputation |
title_full_unstemmed | Altered microstructure rather than morphology in the corpus callosum after lower limb amputation |
title_short | Altered microstructure rather than morphology in the corpus callosum after lower limb amputation |
title_sort | altered microstructure rather than morphology in the corpus callosum after lower limb amputation |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355997/ https://www.ncbi.nlm.nih.gov/pubmed/28303959 http://dx.doi.org/10.1038/srep44780 |
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