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The role of chemotherapy and new targeted agents in the management of primary prostate cancer

While early treatment of primary prostate cancer is very effective, the incidence of primary prostate cancer continues to rise and therefore the detection of men with high-risk non-metastatic prostate cancer and their subsequent management is becoming increasingly important. There continues to be no...

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Autores principales: Kumar, Sanjeev Srinivas, Pacey, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356176/
https://www.ncbi.nlm.nih.gov/pubmed/28344814
http://dx.doi.org/10.1177/2051415816685211
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author Kumar, Sanjeev Srinivas
Pacey, Simon
author_facet Kumar, Sanjeev Srinivas
Pacey, Simon
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description While early treatment of primary prostate cancer is very effective, the incidence of primary prostate cancer continues to rise and therefore the detection of men with high-risk non-metastatic prostate cancer and their subsequent management is becoming increasingly important. There continues to be no molecularly-targeted or chemotherapeutic options with proven, statistically significant survival benefit in this setting. However, there are indications that further risk stratification using molecular features could potentially help distinguish indolent from aggressive prostate cancer, ultimately providing biological markers that could guide a more personalised approach to therapy selection.
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spelling pubmed-53561762017-03-23 The role of chemotherapy and new targeted agents in the management of primary prostate cancer Kumar, Sanjeev Srinivas Pacey, Simon J Clin Urol Changing Face of Prostate Cancer Diagnosis and Management While early treatment of primary prostate cancer is very effective, the incidence of primary prostate cancer continues to rise and therefore the detection of men with high-risk non-metastatic prostate cancer and their subsequent management is becoming increasingly important. There continues to be no molecularly-targeted or chemotherapeutic options with proven, statistically significant survival benefit in this setting. However, there are indications that further risk stratification using molecular features could potentially help distinguish indolent from aggressive prostate cancer, ultimately providing biological markers that could guide a more personalised approach to therapy selection. SAGE Publications 2016-12-01 2016-12 /pmc/articles/PMC5356176/ /pubmed/28344814 http://dx.doi.org/10.1177/2051415816685211 Text en © British Association of Urological Surgeons 2017 http://creativecommons.org/licenses/by-nc/3.0/ This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 3.0 License (http://www.creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Changing Face of Prostate Cancer Diagnosis and Management
Kumar, Sanjeev Srinivas
Pacey, Simon
The role of chemotherapy and new targeted agents in the management of primary prostate cancer
title The role of chemotherapy and new targeted agents in the management of primary prostate cancer
title_full The role of chemotherapy and new targeted agents in the management of primary prostate cancer
title_fullStr The role of chemotherapy and new targeted agents in the management of primary prostate cancer
title_full_unstemmed The role of chemotherapy and new targeted agents in the management of primary prostate cancer
title_short The role of chemotherapy and new targeted agents in the management of primary prostate cancer
title_sort role of chemotherapy and new targeted agents in the management of primary prostate cancer
topic Changing Face of Prostate Cancer Diagnosis and Management
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356176/
https://www.ncbi.nlm.nih.gov/pubmed/28344814
http://dx.doi.org/10.1177/2051415816685211
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