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Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage

The underlying pathology of cerebral microbleeds (CMBs) with mixed lobar and deep distribution remains contentious. The aim of this study was to correlate CMBs distribution to β-amyloid burden in patients with primary intracerebral hemorrhage (ICH). Fourty-seven ICH patients underwent magnetic reson...

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Autores principales: Tsai, Hsin-Hsi, Tsai, Li-Kai, Chen, Ya-Fang, Tang, Sung-Chun, Lee, Bo-Ching, Yen, Ruoh-Fang, Jeng, Jiann-Shing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356186/
https://www.ncbi.nlm.nih.gov/pubmed/28303922
http://dx.doi.org/10.1038/srep44715
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author Tsai, Hsin-Hsi
Tsai, Li-Kai
Chen, Ya-Fang
Tang, Sung-Chun
Lee, Bo-Ching
Yen, Ruoh-Fang
Jeng, Jiann-Shing
author_facet Tsai, Hsin-Hsi
Tsai, Li-Kai
Chen, Ya-Fang
Tang, Sung-Chun
Lee, Bo-Ching
Yen, Ruoh-Fang
Jeng, Jiann-Shing
author_sort Tsai, Hsin-Hsi
collection PubMed
description The underlying pathology of cerebral microbleeds (CMBs) with mixed lobar and deep distribution remains contentious. The aim of this study was to correlate CMBs distribution to β-amyloid burden in patients with primary intracerebral hemorrhage (ICH). Fourty-seven ICH patients underwent magnetic resonance susceptibility-weighted imaging and (11)C-Pittsburgh Compound B positron emission tomography. The amyloid burden was expressed as standardized uptake value ratio with reference to cerebellum, and presented as median (interquartile range). Patients were categorized into the lobar, mixed (both lobar and deep regions), and deep types of CMB. Comparing the lobar (17%), mixed (59.6%) and deep (23.4%) CMB types, the global amyloid burden was significantly higher in the mixed type than the deep type (1.10 [1.03–1.25] vs 1.00 [0.97–1.09], p = 0.011), but lower than in the lobar type (1.48 [1.18–1.50], p = 0.048). On multivariable analysis, the ratio of lobar to deep CMB number was positively correlated with global (p = 0.028) and occipital (p = 0.031) amyloid burden. In primary ICH, patients with lobar and mixed CMB types are associated with increased amyloid burden than patients with deep type. The ratio of lobar to deep CMB number is an independent indicator of cerebral β-amyloid deposition.
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spelling pubmed-53561862017-03-22 Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage Tsai, Hsin-Hsi Tsai, Li-Kai Chen, Ya-Fang Tang, Sung-Chun Lee, Bo-Ching Yen, Ruoh-Fang Jeng, Jiann-Shing Sci Rep Article The underlying pathology of cerebral microbleeds (CMBs) with mixed lobar and deep distribution remains contentious. The aim of this study was to correlate CMBs distribution to β-amyloid burden in patients with primary intracerebral hemorrhage (ICH). Fourty-seven ICH patients underwent magnetic resonance susceptibility-weighted imaging and (11)C-Pittsburgh Compound B positron emission tomography. The amyloid burden was expressed as standardized uptake value ratio with reference to cerebellum, and presented as median (interquartile range). Patients were categorized into the lobar, mixed (both lobar and deep regions), and deep types of CMB. Comparing the lobar (17%), mixed (59.6%) and deep (23.4%) CMB types, the global amyloid burden was significantly higher in the mixed type than the deep type (1.10 [1.03–1.25] vs 1.00 [0.97–1.09], p = 0.011), but lower than in the lobar type (1.48 [1.18–1.50], p = 0.048). On multivariable analysis, the ratio of lobar to deep CMB number was positively correlated with global (p = 0.028) and occipital (p = 0.031) amyloid burden. In primary ICH, patients with lobar and mixed CMB types are associated with increased amyloid burden than patients with deep type. The ratio of lobar to deep CMB number is an independent indicator of cerebral β-amyloid deposition. Nature Publishing Group 2017-03-17 /pmc/articles/PMC5356186/ /pubmed/28303922 http://dx.doi.org/10.1038/srep44715 Text en Copyright © 2017, The Author(s) http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/
spellingShingle Article
Tsai, Hsin-Hsi
Tsai, Li-Kai
Chen, Ya-Fang
Tang, Sung-Chun
Lee, Bo-Ching
Yen, Ruoh-Fang
Jeng, Jiann-Shing
Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage
title Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage
title_full Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage
title_fullStr Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage
title_full_unstemmed Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage
title_short Correlation of Cerebral Microbleed Distribution to Amyloid Burden in Patients with Primary Intracerebral Hemorrhage
title_sort correlation of cerebral microbleed distribution to amyloid burden in patients with primary intracerebral hemorrhage
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356186/
https://www.ncbi.nlm.nih.gov/pubmed/28303922
http://dx.doi.org/10.1038/srep44715
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