Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer

DNA/RNA methylation plays an important role in lung cancer initiation and progression. Liquid biopsy makes use of cells, nucleotides and proteins released from tumor cells into body fluids to help with cancer diagnosis and prognosis. Methylation of circulating tumor DNA (ctDNA) has gained increasing...

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Detalles Bibliográficos
Autores principales: Lu, Yan, Li, Shulin/SL, Zhu, Shiguo/SG, Gong, Yabin/YB, Shi, Jun/J, Xu, Ling/ L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356409/
https://www.ncbi.nlm.nih.gov/pubmed/28331435
http://dx.doi.org/10.1186/s12575-017-0051-8
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author Lu, Yan
Li, Shulin/SL
Zhu, Shiguo/SG
Gong, Yabin/YB
Shi, Jun/J
Xu, Ling/ L
author_facet Lu, Yan
Li, Shulin/SL
Zhu, Shiguo/SG
Gong, Yabin/YB
Shi, Jun/J
Xu, Ling/ L
author_sort Lu, Yan
collection PubMed
description DNA/RNA methylation plays an important role in lung cancer initiation and progression. Liquid biopsy makes use of cells, nucleotides and proteins released from tumor cells into body fluids to help with cancer diagnosis and prognosis. Methylation of circulating tumor DNA (ctDNA) has gained increasing attention as biomarkers for lung cancer. Here we briefly introduce the biological basis and detection method of ctDNA methylation, and review various applications of methylated DNA in body fluids in lung cancer screening, diagnosis, prognosis, monitoring and treatment prediction. We also discuss the emerging role of RNA methylation as biomarkers for cancer.
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spelling pubmed-53564092017-03-22 Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer Lu, Yan Li, Shulin/SL Zhu, Shiguo/SG Gong, Yabin/YB Shi, Jun/J Xu, Ling/ L Biol Proced Online Review DNA/RNA methylation plays an important role in lung cancer initiation and progression. Liquid biopsy makes use of cells, nucleotides and proteins released from tumor cells into body fluids to help with cancer diagnosis and prognosis. Methylation of circulating tumor DNA (ctDNA) has gained increasing attention as biomarkers for lung cancer. Here we briefly introduce the biological basis and detection method of ctDNA methylation, and review various applications of methylated DNA in body fluids in lung cancer screening, diagnosis, prognosis, monitoring and treatment prediction. We also discuss the emerging role of RNA methylation as biomarkers for cancer. BioMed Central 2017-03-17 /pmc/articles/PMC5356409/ /pubmed/28331435 http://dx.doi.org/10.1186/s12575-017-0051-8 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Lu, Yan
Li, Shulin/SL
Zhu, Shiguo/SG
Gong, Yabin/YB
Shi, Jun/J
Xu, Ling/ L
Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer
title Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer
title_full Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer
title_fullStr Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer
title_full_unstemmed Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer
title_short Methylated DNA/RNA in Body Fluids as Biomarkers for Lung Cancer
title_sort methylated dna/rna in body fluids as biomarkers for lung cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356409/
https://www.ncbi.nlm.nih.gov/pubmed/28331435
http://dx.doi.org/10.1186/s12575-017-0051-8
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