Emergence of a novel subclade of influenza A(H3N2) virus in London, December 2016 to January 2017

We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fel...

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Detalles Bibliográficos
Autores principales: Harvala, Heli, Frampton, Dan, Grant, Paul, Raffle, Jade, Ferns, Ruth Bridget, Kozlakidis, Zisis, Kellam, Paul, Pillay, Deenan, Hayward, Andrew, Nastouli, Eleni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2017
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356434/
https://www.ncbi.nlm.nih.gov/pubmed/28251889
http://dx.doi.org/10.2807/1560-7917.ES.2017.22.8.30466
Descripción
Sumario:We report the molecular investigations of a large influenza A(H3N2) outbreak, in a season characterised by sharp increase in influenza admissions since December 2016. Analysis of haemagglutinin (HA) sequences demonstrated co-circulation of multiple clades (3C.3a, 3C.2a and 3C.2a1). Most variants fell into a novel subclade (proposed as 3C.2a2); they possessed four unique amino acid substitutions in the HA protein and loss of a potential glycosylation site. These changes potentially modify the H3N2 strain antigenicity.

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