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Biomarkers to detect membranous nephropathy in Chinese patients

Anti-M-type phospholipase A(2) receptor (anti-PLA(2)R) is a widely accepted biomarker for clinical idiopathic membranous neurophathy (IMN). However, its ability to differentiate between IMN and secondary MN (SMN) is controversial. The objective of this study was to assess clinical MN biomarkers in b...

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Autores principales: Lin, Li, Wang, Wei Ming, Pan, Xiao Xia, Xu, Jing, Gao, Chen Ni, Zhang, Wen, Ren, Hong, Xie, Jing Yuan, Shen, Pin Yan, Xu, Yao Wen, Ni, Li Yan, Chen, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356526/
https://www.ncbi.nlm.nih.gov/pubmed/27634909
http://dx.doi.org/10.18632/oncotarget.12014
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author Lin, Li
Wang, Wei Ming
Pan, Xiao Xia
Xu, Jing
Gao, Chen Ni
Zhang, Wen
Ren, Hong
Xie, Jing Yuan
Shen, Pin Yan
Xu, Yao Wen
Ni, Li Yan
Chen, Nan
author_facet Lin, Li
Wang, Wei Ming
Pan, Xiao Xia
Xu, Jing
Gao, Chen Ni
Zhang, Wen
Ren, Hong
Xie, Jing Yuan
Shen, Pin Yan
Xu, Yao Wen
Ni, Li Yan
Chen, Nan
author_sort Lin, Li
collection PubMed
description Anti-M-type phospholipase A(2) receptor (anti-PLA(2)R) is a widely accepted biomarker for clinical idiopathic membranous neurophathy (IMN). However, its ability to differentiate between IMN and secondary MN (SMN) is controversial. The objective of this study was to assess clinical MN biomarkers in blood, tissue and urine samples from Chinese patients. In total, 195 MN patients and 70 patients with other glomerular diseases were prospectively enrolled in the study. Participants were followed up for average of 17 months (range 3-39 months). Anti-PLA(2)R and anti-THSD7A (thrombospondin type-1 domain-containing 7A) were detected only in MN patient sera and not in controls. Serum anti-THSD7A and THSD7A-positive biopsies were detected in 1/18 and 2/18 PLA(2)R-negative MN cases, respectively. PLA(2)R and THSD7A were detected in 72.27% and 40% of SMN cases, respectively. While serum positivity for both anti-PLA(2)R and anti-THSD7A at the time of renal biopsy was specific to MN patients, neither antigen could discriminate between primary and secondary MN. We also found that high urinary levels of retinol binding protein (RBP) predicted poor proteinuria outcomes in study participants. Patients with low or medium urinary RBP levels achieved remission more frequently than those with high RBP.
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spelling pubmed-53565262017-03-24 Biomarkers to detect membranous nephropathy in Chinese patients Lin, Li Wang, Wei Ming Pan, Xiao Xia Xu, Jing Gao, Chen Ni Zhang, Wen Ren, Hong Xie, Jing Yuan Shen, Pin Yan Xu, Yao Wen Ni, Li Yan Chen, Nan Oncotarget Research Paper: Immunology Anti-M-type phospholipase A(2) receptor (anti-PLA(2)R) is a widely accepted biomarker for clinical idiopathic membranous neurophathy (IMN). However, its ability to differentiate between IMN and secondary MN (SMN) is controversial. The objective of this study was to assess clinical MN biomarkers in blood, tissue and urine samples from Chinese patients. In total, 195 MN patients and 70 patients with other glomerular diseases were prospectively enrolled in the study. Participants were followed up for average of 17 months (range 3-39 months). Anti-PLA(2)R and anti-THSD7A (thrombospondin type-1 domain-containing 7A) were detected only in MN patient sera and not in controls. Serum anti-THSD7A and THSD7A-positive biopsies were detected in 1/18 and 2/18 PLA(2)R-negative MN cases, respectively. PLA(2)R and THSD7A were detected in 72.27% and 40% of SMN cases, respectively. While serum positivity for both anti-PLA(2)R and anti-THSD7A at the time of renal biopsy was specific to MN patients, neither antigen could discriminate between primary and secondary MN. We also found that high urinary levels of retinol binding protein (RBP) predicted poor proteinuria outcomes in study participants. Patients with low or medium urinary RBP levels achieved remission more frequently than those with high RBP. Impact Journals LLC 2016-09-13 /pmc/articles/PMC5356526/ /pubmed/27634909 http://dx.doi.org/10.18632/oncotarget.12014 Text en Copyright: © 2016 Lin et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper: Immunology
Lin, Li
Wang, Wei Ming
Pan, Xiao Xia
Xu, Jing
Gao, Chen Ni
Zhang, Wen
Ren, Hong
Xie, Jing Yuan
Shen, Pin Yan
Xu, Yao Wen
Ni, Li Yan
Chen, Nan
Biomarkers to detect membranous nephropathy in Chinese patients
title Biomarkers to detect membranous nephropathy in Chinese patients
title_full Biomarkers to detect membranous nephropathy in Chinese patients
title_fullStr Biomarkers to detect membranous nephropathy in Chinese patients
title_full_unstemmed Biomarkers to detect membranous nephropathy in Chinese patients
title_short Biomarkers to detect membranous nephropathy in Chinese patients
title_sort biomarkers to detect membranous nephropathy in chinese patients
topic Research Paper: Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356526/
https://www.ncbi.nlm.nih.gov/pubmed/27634909
http://dx.doi.org/10.18632/oncotarget.12014
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