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Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma
The androgen receptor (AR) is involved in the differentiation and growth of many cancers. We hypothesized that two microsatellite polymorphic variants, AR (CAG)n and (GGN)n repeats, were also associated with the development of Papillary thyroid cancer (PTC) and Osteosarcoma. In current study, we con...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356545/ https://www.ncbi.nlm.nih.gov/pubmed/27626686 http://dx.doi.org/10.18632/oncotarget.11902 |
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author | Shi, Yongxiang Chen, Weishan Li, Qinghuai Ye, Zhaoming |
author_facet | Shi, Yongxiang Chen, Weishan Li, Qinghuai Ye, Zhaoming |
author_sort | Shi, Yongxiang |
collection | PubMed |
description | The androgen receptor (AR) is involved in the differentiation and growth of many cancers. We hypothesized that two microsatellite polymorphic variants, AR (CAG)n and (GGN)n repeats, were also associated with the development of Papillary thyroid cancer (PTC) and Osteosarcoma. In current study, we conducted two case-control studies in a Chinese population to investigate the possible relationship between these two AR repeat polymorphisms and the risk of PTC and Osteosarcoma. The AR CAG repeat length was significantly associated with both risk of PTC and Osteosarcoma. Subjects with shorter AR CAG repeats had a higher risk of developing PTC (OR = 1.47, 95% CI: 1.17–1.85, P = 0.001) and Osteosarcoma (OR = 1.53, 95% CI: 1.19–1.97, P = 9.2 × 10(–4)). Specifically, shorter GGN repeats also contribute a significant increased risk of Osteosarcoma (OR = 1.35, 95% CI: 1.03–1.77, P = 0.030). Our results contribute to a better understanding of the complex hormone related mechanisms underlying PTC and Osteosarcoma. |
format | Online Article Text |
id | pubmed-5356545 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53565452017-03-24 Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma Shi, Yongxiang Chen, Weishan Li, Qinghuai Ye, Zhaoming Oncotarget Research Paper The androgen receptor (AR) is involved in the differentiation and growth of many cancers. We hypothesized that two microsatellite polymorphic variants, AR (CAG)n and (GGN)n repeats, were also associated with the development of Papillary thyroid cancer (PTC) and Osteosarcoma. In current study, we conducted two case-control studies in a Chinese population to investigate the possible relationship between these two AR repeat polymorphisms and the risk of PTC and Osteosarcoma. The AR CAG repeat length was significantly associated with both risk of PTC and Osteosarcoma. Subjects with shorter AR CAG repeats had a higher risk of developing PTC (OR = 1.47, 95% CI: 1.17–1.85, P = 0.001) and Osteosarcoma (OR = 1.53, 95% CI: 1.19–1.97, P = 9.2 × 10(–4)). Specifically, shorter GGN repeats also contribute a significant increased risk of Osteosarcoma (OR = 1.35, 95% CI: 1.03–1.77, P = 0.030). Our results contribute to a better understanding of the complex hormone related mechanisms underlying PTC and Osteosarcoma. Impact Journals LLC 2016-09-08 /pmc/articles/PMC5356545/ /pubmed/27626686 http://dx.doi.org/10.18632/oncotarget.11902 Text en Copyright: © 2016 Shi et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Shi, Yongxiang Chen, Weishan Li, Qinghuai Ye, Zhaoming Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma |
title | Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma |
title_full | Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma |
title_fullStr | Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma |
title_full_unstemmed | Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma |
title_short | Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma |
title_sort | androgen receptor cag and ggn repeat length variation contributes more to the tumorigenesis of osteosarcoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356545/ https://www.ncbi.nlm.nih.gov/pubmed/27626686 http://dx.doi.org/10.18632/oncotarget.11902 |
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