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Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma

The androgen receptor (AR) is involved in the differentiation and growth of many cancers. We hypothesized that two microsatellite polymorphic variants, AR (CAG)n and (GGN)n repeats, were also associated with the development of Papillary thyroid cancer (PTC) and Osteosarcoma. In current study, we con...

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Detalles Bibliográficos
Autores principales: Shi, Yongxiang, Chen, Weishan, Li, Qinghuai, Ye, Zhaoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356545/
https://www.ncbi.nlm.nih.gov/pubmed/27626686
http://dx.doi.org/10.18632/oncotarget.11902
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author Shi, Yongxiang
Chen, Weishan
Li, Qinghuai
Ye, Zhaoming
author_facet Shi, Yongxiang
Chen, Weishan
Li, Qinghuai
Ye, Zhaoming
author_sort Shi, Yongxiang
collection PubMed
description The androgen receptor (AR) is involved in the differentiation and growth of many cancers. We hypothesized that two microsatellite polymorphic variants, AR (CAG)n and (GGN)n repeats, were also associated with the development of Papillary thyroid cancer (PTC) and Osteosarcoma. In current study, we conducted two case-control studies in a Chinese population to investigate the possible relationship between these two AR repeat polymorphisms and the risk of PTC and Osteosarcoma. The AR CAG repeat length was significantly associated with both risk of PTC and Osteosarcoma. Subjects with shorter AR CAG repeats had a higher risk of developing PTC (OR = 1.47, 95% CI: 1.17–1.85, P = 0.001) and Osteosarcoma (OR = 1.53, 95% CI: 1.19–1.97, P = 9.2 × 10(–4)). Specifically, shorter GGN repeats also contribute a significant increased risk of Osteosarcoma (OR = 1.35, 95% CI: 1.03–1.77, P = 0.030). Our results contribute to a better understanding of the complex hormone related mechanisms underlying PTC and Osteosarcoma.
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spelling pubmed-53565452017-03-24 Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma Shi, Yongxiang Chen, Weishan Li, Qinghuai Ye, Zhaoming Oncotarget Research Paper The androgen receptor (AR) is involved in the differentiation and growth of many cancers. We hypothesized that two microsatellite polymorphic variants, AR (CAG)n and (GGN)n repeats, were also associated with the development of Papillary thyroid cancer (PTC) and Osteosarcoma. In current study, we conducted two case-control studies in a Chinese population to investigate the possible relationship between these two AR repeat polymorphisms and the risk of PTC and Osteosarcoma. The AR CAG repeat length was significantly associated with both risk of PTC and Osteosarcoma. Subjects with shorter AR CAG repeats had a higher risk of developing PTC (OR = 1.47, 95% CI: 1.17–1.85, P = 0.001) and Osteosarcoma (OR = 1.53, 95% CI: 1.19–1.97, P = 9.2 × 10(–4)). Specifically, shorter GGN repeats also contribute a significant increased risk of Osteosarcoma (OR = 1.35, 95% CI: 1.03–1.77, P = 0.030). Our results contribute to a better understanding of the complex hormone related mechanisms underlying PTC and Osteosarcoma. Impact Journals LLC 2016-09-08 /pmc/articles/PMC5356545/ /pubmed/27626686 http://dx.doi.org/10.18632/oncotarget.11902 Text en Copyright: © 2016 Shi et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Shi, Yongxiang
Chen, Weishan
Li, Qinghuai
Ye, Zhaoming
Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma
title Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma
title_full Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma
title_fullStr Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma
title_full_unstemmed Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma
title_short Androgen receptor CAG and GGN repeat length variation contributes more to the tumorigenesis of osteosarcoma
title_sort androgen receptor cag and ggn repeat length variation contributes more to the tumorigenesis of osteosarcoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356545/
https://www.ncbi.nlm.nih.gov/pubmed/27626686
http://dx.doi.org/10.18632/oncotarget.11902
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