Binding of human recombinant mutant soluble ectodomain of FGFR2IIIc to c subtype of FGFRs: implications for anticancer activity

FGFRs are considered essential targets for cancer therapy. We previously reported that msFGFR2c, a Ser252Trp mutant soluble ectodomain of FGFR2IIIc, inhibited tumor growth by blocking FGF signaling pathway. However, the underlying molecular mechanism is still obscure. In this study, we reported that...

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Detalles Bibliográficos
Autores principales: Liu, Zhong, Liu, Ge, Zhang, Guang-Lin, Li, Jun, He, Yan-Qing, Zhang, Shu-Shu, Wang, Yi, He, Wei-Yi, Cheng, Guo-Hua, Yang, Xuesong, Xu, Jun, Wang, Ju
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356568/
https://www.ncbi.nlm.nih.gov/pubmed/28049184
http://dx.doi.org/10.18632/oncotarget.12067

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