Heparins that block VEGF-A-mediated von Willebrand factor fiber generation are potent inhibitors of hematogenous but not lymphatic metastasis

Von Willebrand factor (VWF) serves as a nidus for platelet aggregation and thrombosis. We hypothesize that VWF fibers contribute to the development of venous thromboembolism (VTE) and to metastasis formation. Here, we show that vascular and lymphatic endothelial cells (ECs) express VWF in vitro and...

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Detalles Bibliográficos
Autores principales: Goertz, Lukas, Schneider, Stefan Werner, Desch, Anna, Mayer, Frank Thomas, Koett, Julian, Nowak, Kai, Karampinis, Ioannis, Bohlmann, Michael K., Umansky, Viktor, Bauer, Alexander Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356571/
https://www.ncbi.nlm.nih.gov/pubmed/27602496
http://dx.doi.org/10.18632/oncotarget.11832

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