The somatic POLE P286R mutation defines a unique subclass of colorectal cancer featuring hypermutation, representing a potential genomic biomarker for immunotherapy

Early-onset colorectal cancers (EOCRCs) may have biological or genomic features distinct from late-onset CRCs (LOCRCs). Previous studies have mostly focused on the germline predisposition conditions of EOCRCs, but we hypothesized that EOCRCs may have distinct somatic aberrations that accelerate canc...

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Detalles Bibliográficos
Autores principales: Ahn, Sung-Min, Ansari, Adnan Ahmad, Kim, Jihun, Kim, Deokhoon, Chun, Sung-Min, Kim, Jiyun, Kim, Tae Won, Park, Inja, Yu, Chang-Sik, Jang, Se Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356579/
https://www.ncbi.nlm.nih.gov/pubmed/27612425
http://dx.doi.org/10.18632/oncotarget.11862

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