Arctigenin functions as a selective agonist of estrogen receptor β to restrict mTORC1 activation and consequent Th17 differentiation

Arctigenin was previously proven to inhibit Th17 cell differentiation and thereby attenuate colitis in mice by down-regulating the activation of mechanistic target of rapamycin complex 1 (mTORC1). The present study was performed to address its underlying mechanism in view of estrogen receptor (ER)....

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Detalles Bibliográficos
Autores principales: Wu, Xin, Tong, Bei, Yang, Yan, Luo, Jinque, Yuan, Xusheng, Wei, Zhifeng, Yue, Mengfan, Xia, Yufeng, Dai, Yue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper: Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356633/
https://www.ncbi.nlm.nih.gov/pubmed/27863380
http://dx.doi.org/10.18632/oncotarget.13338

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