Hypermethylation of the HIC1 promoter and aberrant expression of HIC1/SIRT1 contribute to the development of thyroid papillary carcinoma

Hypermethylation leading to the loss of hypermethylated in cancer-1 (HIC1) gene expression occurs in many different types of human cancer. HIC1 is a transcriptional repressor that directly binds to the promoter region of NAD-dependent deacetylase sirtuin-1 (SIRT1). SIRT1 functions in cell growth, is...

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Detalles Bibliográficos
Autores principales: Wu, Wenyi, Zhang, Liting, Lin, Jianqing, Huang, Hanwei, Shi, Bai, Lin, Xingong, Huang, Zhongxin, Wang, Chaoyang, Qiu, Jianlong, Wei, Xiaolong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356670/
https://www.ncbi.nlm.nih.gov/pubmed/27793057
http://dx.doi.org/10.18632/oncotarget.12936

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