MED12 mutations in breast phyllodes tumors: evidence of temporal tumoral heterogeneity and identification of associated critical signaling pathways

Exome sequencing has recently identified highly recurrent MED12 somatic mutations in fibroadenomas (FAs) and phyllodes tumors (PTs). In the present study, based on a large series, we confirmed the presence of MED12 exon 1 and 2 mutations in 49% (41/83) of PTs, 70% (7/10) of FAs and 9.1% (1/11) of fi...

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Detalles Bibliográficos
Autores principales: Laé, Marick, Gardrat, Sophie, Rondeau, Sophie, Richardot, Camille, Caly, Martial, Chemlali, Walid, Vacher, Sophie, Couturier, Jérôme, Mariani, Odette, Terrier, Philippe, Bièche, Ivan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356671/
https://www.ncbi.nlm.nih.gov/pubmed/27806318
http://dx.doi.org/10.18632/oncotarget.12991

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