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Loss of phosphodiesterase 4D mediates acquired triapine resistance via Epac-Rap1-Integrin signaling
Triapine, an anticancer thiosemicarbazone, is currently under clinical investigation. Whereas promising results were obtained in hematological diseases, trials in solid tumors widely failed. To understand mechanisms causing triapine insensitivity, we have analysed genomic alterations in a triapine-r...
Autores principales: | Miklos, Walter, Heffeter, Petra, Pirker, Christine, Hager, Sonja, Kowol, Christian R., van Schoonhoven, Sushilla, Stojanovic, Mirjana, Keppler, Bernhard K., Berger, Walter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356681/ https://www.ncbi.nlm.nih.gov/pubmed/27602951 http://dx.doi.org/10.18632/oncotarget.11821 |
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