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KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients
Numerous studies showed abnormal expression of ion channels in different cancer types. Amongst these, the potassium channel gene KCNJ3 (encoding for GIRK1 proteins) has been reported to be upregulated in tumors of patients with breast cancer and to correlate with positive lymph node status. We aimed...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356693/ https://www.ncbi.nlm.nih.gov/pubmed/27835900 http://dx.doi.org/10.18632/oncotarget.13224 |
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author | Kammerer, Sarah Sokolowski, Armin Hackl, Hubert Platzer, Dieter Jahn, Stephan Wenzel El-Heliebi, Amin Schwarzenbacher, Daniela Stiegelbauer, Verena Pichler, Martin Rezania, Simin Fiegl, Heidelinde Peintinger, Florentia Regitnig, Peter Hoefler, Gerald Schreibmayer, Wolfgang Bauernhofer, Thomas |
author_facet | Kammerer, Sarah Sokolowski, Armin Hackl, Hubert Platzer, Dieter Jahn, Stephan Wenzel El-Heliebi, Amin Schwarzenbacher, Daniela Stiegelbauer, Verena Pichler, Martin Rezania, Simin Fiegl, Heidelinde Peintinger, Florentia Regitnig, Peter Hoefler, Gerald Schreibmayer, Wolfgang Bauernhofer, Thomas |
author_sort | Kammerer, Sarah |
collection | PubMed |
description | Numerous studies showed abnormal expression of ion channels in different cancer types. Amongst these, the potassium channel gene KCNJ3 (encoding for GIRK1 proteins) has been reported to be upregulated in tumors of patients with breast cancer and to correlate with positive lymph node status. We aimed to study KCNJ3 levels in different breast cancer subtypes using gene expression data from the TCGA, to validate our findings using RNA in situ hybridization in a validation cohort (GEO ID GSE17705), and to study the prognostic value of KCNJ3 using survival analysis. In a total of > 1000 breast cancer patients of two independent data sets we showed a) that KCNJ3 expression is upregulated in tumor tissue compared to corresponding normal tissue (p < 0.001), b) that KCNJ3 expression is associated with estrogen receptor (ER) positive tumors (p < 0.001), but that KCNJ3 expression is variable within this group, and c) that ER positive patients with high KCNJ3 levels have worse overall (p < 0.05) and disease free survival probabilities (p < 0.01), whereby KCNJ3 is an independent prognostic factor (p <0.05). In conclusion, our data suggest that patients with ER positive breast cancer might be stratified into high risk and low risk groups based on the KCNJ3 levels in the tumor. |
format | Online Article Text |
id | pubmed-5356693 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53566932017-04-26 KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients Kammerer, Sarah Sokolowski, Armin Hackl, Hubert Platzer, Dieter Jahn, Stephan Wenzel El-Heliebi, Amin Schwarzenbacher, Daniela Stiegelbauer, Verena Pichler, Martin Rezania, Simin Fiegl, Heidelinde Peintinger, Florentia Regitnig, Peter Hoefler, Gerald Schreibmayer, Wolfgang Bauernhofer, Thomas Oncotarget Research Paper Numerous studies showed abnormal expression of ion channels in different cancer types. Amongst these, the potassium channel gene KCNJ3 (encoding for GIRK1 proteins) has been reported to be upregulated in tumors of patients with breast cancer and to correlate with positive lymph node status. We aimed to study KCNJ3 levels in different breast cancer subtypes using gene expression data from the TCGA, to validate our findings using RNA in situ hybridization in a validation cohort (GEO ID GSE17705), and to study the prognostic value of KCNJ3 using survival analysis. In a total of > 1000 breast cancer patients of two independent data sets we showed a) that KCNJ3 expression is upregulated in tumor tissue compared to corresponding normal tissue (p < 0.001), b) that KCNJ3 expression is associated with estrogen receptor (ER) positive tumors (p < 0.001), but that KCNJ3 expression is variable within this group, and c) that ER positive patients with high KCNJ3 levels have worse overall (p < 0.05) and disease free survival probabilities (p < 0.01), whereby KCNJ3 is an independent prognostic factor (p <0.05). In conclusion, our data suggest that patients with ER positive breast cancer might be stratified into high risk and low risk groups based on the KCNJ3 levels in the tumor. Impact Journals LLC 2016-11-08 /pmc/articles/PMC5356693/ /pubmed/27835900 http://dx.doi.org/10.18632/oncotarget.13224 Text en Copyright: © 2016 Kammerer et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Paper Kammerer, Sarah Sokolowski, Armin Hackl, Hubert Platzer, Dieter Jahn, Stephan Wenzel El-Heliebi, Amin Schwarzenbacher, Daniela Stiegelbauer, Verena Pichler, Martin Rezania, Simin Fiegl, Heidelinde Peintinger, Florentia Regitnig, Peter Hoefler, Gerald Schreibmayer, Wolfgang Bauernhofer, Thomas KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients |
title | KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients |
title_full | KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients |
title_fullStr | KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients |
title_full_unstemmed | KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients |
title_short | KCNJ3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients |
title_sort | kcnj3 is a new independent prognostic marker for estrogen receptor positive breast cancer patients |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356693/ https://www.ncbi.nlm.nih.gov/pubmed/27835900 http://dx.doi.org/10.18632/oncotarget.13224 |
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