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PD 0332991, a selective cyclin D kinase 4/6 inhibitor, sensitizes lung cancer cells to treatment with epidermal growth factor receptor tyrosine kinase inhibitors

Acquired resistance to epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) is a major challenge to targeted therapy for non-small cell lung cancer (NSCLC). We investigated whether a cyclin D kinase 4/6 (CDK4/6) inhibitor, PD 0332991, could reverse EGFR-TKI resistance in human lun...

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Detalles Bibliográficos
Autores principales:	Liu, Minghui, Xu, Song, Wang, Yuli, Li, Ying, Li, Yongwen, Zhang, Hongbing, Liu, Hongyu, Chen, Jun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356711/ https://www.ncbi.nlm.nih.gov/pubmed/27825114 http://dx.doi.org/10.18632/oncotarget.13069

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