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Oncolytic adenovirus coexpressing interleukin-12 and shVEGF restores antitumor immune function and enhances antitumor efficacy

Tumor microenvironment is extremely immunosuppressive, preventing efficient induction of antitumor immunity. To overcome tumor-mediated immunosuppression and enhance the potency of immunogene therapy, oncolytic adenovirus (Ad) co-expressing interleukin (IL)-12 and vascular endothelial growth factor...

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Detalles Bibliográficos
Autores principales:	Ahn, Hyo Min, Hong, JinWoo, Yun, Chae-Ok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356712/ https://www.ncbi.nlm.nih.gov/pubmed/27821803 http://dx.doi.org/10.18632/oncotarget.13087

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