PTEN dephosphorylates AKT to prevent the expression of GLUT1 on plasmamembrane and to limit glucose consumption in cancer cells

GLUT1 is the facilitative transporter playing the major role in the internalization of glucose. Basally, GLUT1 resides on vesicles located in a para-golgian area, and is translocated onto the plasmamembrane upon activation of the PI3KC1-AKT pathway. In proliferating cancer cells, which demand a high...

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Detalles Bibliográficos
Autores principales: Phadngam, Suratchanee, Castiglioni, Andrea, Ferraresi, Alessandra, Morani, Federica, Follo, Carlo, Isidoro, Ciro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356715/
https://www.ncbi.nlm.nih.gov/pubmed/27829222
http://dx.doi.org/10.18632/oncotarget.13113

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356715/
https://www.ncbi.nlm.nih.gov/pubmed/27829222
http://dx.doi.org/10.18632/oncotarget.13113

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