Identification of an HSP90 modulated multi-step process for ERBB2 degradation in breast cancer cells

The receptor tyrosine kinase ERBB2 interacts with HSP90 and is overexpressed in aggressive breast cancers. Therapeutic HSP90 inhibitors, i.e. Geldanamycin (GA), target ERBB2 to degradation. We have previously shown that HSP90 is responsible for the missorting of recycling ERBB2 to degradation compar...

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Detalles Bibliográficos
Autores principales: Castagnola, Patrizio, Bellese, Grazia, Birocchi, Filippo, Gagliani, Maria Cristina, Tacchetti, Carlo, Cortese, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356745/
https://www.ncbi.nlm.nih.gov/pubmed/27863425
http://dx.doi.org/10.18632/oncotarget.13392

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356745/
https://www.ncbi.nlm.nih.gov/pubmed/27863425
http://dx.doi.org/10.18632/oncotarget.13392

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