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Choroidal microvascular proliferation secondary to diabetes mellitus

Diabetes is a common endocrine disorder associated with peripheral microvascular diseases such as proliferative retinal microangiopathy (or diabetic retinopathy), which may lead to blindness. Unfortunately, diabetic microvascular abnormalities in the choroid are underestimated in clinical practice....

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Detalles Bibliográficos
Autores principales: Hua, Rui, Qing, Li, Wong, Ian Yat Hin, Ning, Hong, Wang, Hailin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356776/
https://www.ncbi.nlm.nih.gov/pubmed/28008140
http://dx.doi.org/10.18632/oncotarget.14020
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author Hua, Rui
Qing, Li
Wong, Ian Yat Hin
Ning, Hong
Wang, Hailin
author_facet Hua, Rui
Qing, Li
Wong, Ian Yat Hin
Ning, Hong
Wang, Hailin
author_sort Hua, Rui
collection PubMed
description Diabetes is a common endocrine disorder associated with peripheral microvascular diseases such as proliferative retinal microangiopathy (or diabetic retinopathy), which may lead to blindness. Unfortunately, diabetic microvascular abnormalities in the choroid are underestimated in clinical practice. Recent literature has revealed that the severity of diabetic retinopathy is aggravated by choroidopathy resulting from hyperglycemia. Here, we introduce a case of diabetic retinopathy with choroidal neovascularization membrane but without signs of retinal microvascular proliferation or drusen. We investigated the pathogenesis of choroidal microvascular proliferation secondary to diabetes. We postulate that choroidal neovascularization is an intraocular microvascular complication of diabetes mellitus. Intravitreal anti-vascular endothelial growth factor therapy may be a treatment option for microvascular proliferation in both retina and choroids.
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spelling pubmed-53567762017-04-20 Choroidal microvascular proliferation secondary to diabetes mellitus Hua, Rui Qing, Li Wong, Ian Yat Hin Ning, Hong Wang, Hailin Oncotarget Research Paper: Pathology Diabetes is a common endocrine disorder associated with peripheral microvascular diseases such as proliferative retinal microangiopathy (or diabetic retinopathy), which may lead to blindness. Unfortunately, diabetic microvascular abnormalities in the choroid are underestimated in clinical practice. Recent literature has revealed that the severity of diabetic retinopathy is aggravated by choroidopathy resulting from hyperglycemia. Here, we introduce a case of diabetic retinopathy with choroidal neovascularization membrane but without signs of retinal microvascular proliferation or drusen. We investigated the pathogenesis of choroidal microvascular proliferation secondary to diabetes. We postulate that choroidal neovascularization is an intraocular microvascular complication of diabetes mellitus. Intravitreal anti-vascular endothelial growth factor therapy may be a treatment option for microvascular proliferation in both retina and choroids. Impact Journals LLC 2016-12-19 /pmc/articles/PMC5356776/ /pubmed/28008140 http://dx.doi.org/10.18632/oncotarget.14020 Text en Copyright: © 2017 Hua et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper: Pathology
Hua, Rui
Qing, Li
Wong, Ian Yat Hin
Ning, Hong
Wang, Hailin
Choroidal microvascular proliferation secondary to diabetes mellitus
title Choroidal microvascular proliferation secondary to diabetes mellitus
title_full Choroidal microvascular proliferation secondary to diabetes mellitus
title_fullStr Choroidal microvascular proliferation secondary to diabetes mellitus
title_full_unstemmed Choroidal microvascular proliferation secondary to diabetes mellitus
title_short Choroidal microvascular proliferation secondary to diabetes mellitus
title_sort choroidal microvascular proliferation secondary to diabetes mellitus
topic Research Paper: Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356776/
https://www.ncbi.nlm.nih.gov/pubmed/28008140
http://dx.doi.org/10.18632/oncotarget.14020
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AT wongianyathin choroidalmicrovascularproliferationsecondarytodiabetesmellitus
AT ninghong choroidalmicrovascularproliferationsecondarytodiabetesmellitus
AT wanghailin choroidalmicrovascularproliferationsecondarytodiabetesmellitus