Cargando…

Icariside II activates EGFR-Akt-Nrf2 signaling and protects osteoblasts from dexamethasone

The potential effect of icariside II on dexamethasone-induced osteoblast cell damages was evaluated here. In MC3T3-E1 osteoblastic cells and the primary murine osteoblasts, co-treatment with icariside II dramatically attenuated dexamethasone- induced cell death and apoptosis. Icariside II activated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Weidong, Mao, Li, Ji, Feng, Chen, Fengli, Wang, Shouguo, Xie, Yue
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356826/ https://www.ncbi.nlm.nih.gov/pubmed/27911877 http://dx.doi.org/10.18632/oncotarget.13732

Ejemplares similares

MicroRNA-200a activates Nrf2 signaling to protect osteoblasts from dexamethasone
por: Zhao, Sai, et al.
Publicado: (2017)

miR-107 inhibition upregulates CAB39 and activates AMPK-Nrf2 signaling to protect osteoblasts from dexamethasone-induced oxidative injury and cytotoxicity
por: Zhuang, Yu, et al.
Publicado: (2020)

Icariside II Enhances Nrf2 Nuclear Translocation to Upregulate Phase II Detoxifying Enzyme Expression Coupled with the ERK, Akt and JNK Signaling Pathways
por: Gu, Jing, et al.
Publicado: (2011)

PGK1 depletion activates Nrf2 signaling to protect human osteoblasts from dexamethasone
por: Liang, Jinqian, et al.
Publicado: (2019)

Comparative Pharmacokinetics Study of Icariin and Icariside II in Rats
por: Cheng, Tao, et al.
Publicado: (2015)

Icariside II Attenuates Methamphetamine-Induced Neurotoxicity and Behavioral Impairments via Activating the Keap1-Nrf2 Pathway
por: Huang, Jian, et al.
Publicado: (2022)

Targeting Apoptosis and Multiple Signaling Pathways with Icariside II in Cancer Cells
por: Khan, Muhammad, et al.
Publicado: (2015)

Icariside II induces rapid phosphorylation of endothelial nitric oxide synthase via multiple signaling pathways
por: Song, Wenpeng, et al.
Publicado: (2022)

Epimedin C protects dexamethasone-induced osteoblasts through NRF1/RhoA pathway
por: Huang, Mi, et al.
Publicado: (2023)

Icariside Ⅱ Attenuates Palmitic Acid-Induced Endothelial Dysfunction Through SRPK1-Akt-eNOS Signaling Pathway
por: Gu, Yang-Yang, et al.
Publicado: (2022)

The Impact of Icariside II on Human Prostate Cancer Cell Proliferation, Mobility, and Autophagy via PI3K-AKT-mTOR Signaling Pathway
por: Li, Shuang, et al.
Publicado: (2020)

FGF23 protects osteoblasts from dexamethasone-induced oxidative injury
por: Ji, Feng, et al.
Publicado: (2020)

Prophylactic Protective Effects and Its Potential Mechanisms of IcarisideII on Streptozotocin Induced Spermatogenic Dysfunction
por: Xu, Yongde, et al.
Publicado: (2014)

Icariside II: Anticancer Potential and Molecular Targets in Solid Cancers
por: Xu, Fei, et al.
Publicado: (2021)

Icariside II ameliorates myocardial ischemia and reperfusion injury by attenuating inflammation and apoptosis through the regulation of the PI3K/AKT signaling pathway
por: Guan, Bing-Feng, et al.
Publicado: (2020)

microRNA-19a protects osteoblasts from dexamethasone via targeting TSC1
por: Liu, Gang, et al.
Publicado: (2017)

Effects of icariside II on brain tissue oxidative stress and Nrf2/HO-1 expression in rats with cerebral ischemia-reperfusion injury
por: Li, Yan, et al.
Publicado: (2019)

Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats
por: Tian, Wenjie, et al.
Publicado: (2015)

Icariside II protects cardiomyocytes from hypoxia-induced injury by upregulating the miR-7-5p/BTG2 axis and activating the PI3K/Akt signaling pathway
por: Hu, Dongxia, et al.
Publicado: (2020)

Tabersonine ameliorates osteoblast apoptosis in rats with dexamethasone-induced osteoporosis by regulating the Nrf2/ROS/Bax signalling pathway
por: Sun, Xi, et al.
Publicado: (2020)

AB209. Prophylactic protective effects and its potential mechanisms of icariside II on streptozotocin induced spermatogenic dysfunction
por: Xu, Yongde, et al.
Publicado: (2015)

Icariside II, a Naturally Occurring SIRT3 Agonist, Protects against Myocardial Infarction through the AMPK/PGC-1α/Apoptosis Signaling Pathway
por: Li, Yeli, et al.
Publicado: (2022)

The Anticancer Properties of Herba Epimedii and Its Main Bioactive Componentsicariin and Icariside II
por: Chen, Meixia, et al.
Publicado: (2016)

Icariside II Induces Apoptosis in U937 Acute Myeloid Leukemia Cells: Role of Inactivation of STAT3-Related Signaling
por: Kang, Sang-Hun, et al.
Publicado: (2012)

Icariin and Icariside II Reciprocally Stimulate Osteogenesis and Inhibit Adipogenesis of Multipotential Stromal Cells through ERK Signaling
por: Zhang, Dawei, et al.
Publicado: (2021)

Activation of Nrf2 by MIND4-17 protects osteoblasts from hydrogen peroxide-induced oxidative stress
por: Guo, Shiguang, et al.
Publicado: (2017)

Synthesis and Biological Evaluation of Novel Alkyl Amine Substituted Icariside II Derivatives as Potential Anticancer Agents
por: Wu, Tong, et al.
Publicado: (2018)

AB176. Icariside II ameliorates diabetic nephropathy in streptozotocin-induced diabetic rats
por: Tian, Wenjie, et al.
Publicado: (2015)

TPGS/Phospholipids Mixed Micelles for Delivery of Icariside II to Multidrug-Resistant Breast Cancer
por: Song, Jie, et al.
Publicado: (2015)

Visual Sensing of β-Glucosidase From Intestinal Fungus in the Generation of Cytotoxic Icarisid II
por: Wang, Gang, et al.
Publicado: (2022)

DCAF1-targeting microRNA-3175 activates Nrf2 signaling and inhibits dexamethasone-induced oxidative injury in human osteoblasts
por: Chen, Jing, et al.
Publicado: (2021)

Gastrodin protects MC3T3-E1 osteoblasts from dexamethasone-induced cellular dysfunction and promotes bone formation via induction of the NRF2 signaling pathway
por: Liu, Shengye, et al.
Publicado: (2018)

Phosphoglycerate kinase 1 silencing by a novel microRNA microRNA-4523 protects human osteoblasts from dexamethasone through activation of Nrf2 signaling cascade
por: Liang, Jin-qian, et al.
Publicado: (2021)

Targeted activation of AMPK by GSK621 ameliorates H(2)O(2)-induced damages in osteoblasts
por: Liu, Weidong, et al.
Publicado: (2017)

Icariside II overcomes TRAIL resistance of melanoma cells through ROS-mediated downregulation of STAT3/cFLIP signaling
por: Du, Juan, et al.
Publicado: (2016)

Optimized Biotransformation of Icariin into Icariside II by β-Glucosidase from Trichoderma viride Using Central Composite Design Method
por: Cheng, Tao, et al.
Publicado: (2016)

Erxian Decoction Attenuates TNF-α Induced Osteoblast Apoptosis by Modulating the Akt/Nrf2/HO-1 Signaling Pathway
por: Wang, Nani, et al.
Publicado: (2019)

Curcumin Protects Osteoblasts From Oxidative Stress-Induced Dysfunction via GSK3β-Nrf2 Signaling Pathway
por: Li, Xumin, et al.
Publicado: (2020)

Effects of Icariside II on Corpus Cavernosum and Major Pelvic Ganglion Neuropathy in Streptozotocin-Induced Diabetic Rats
por: Bai, Guang-Yi, et al.
Publicado: (2014)

Icariside II enhances cisplatin-induced apoptosis by promoting endoplasmic reticulum stress signalling in non-small cell lung cancer cells
por: Tang, Zhao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_tpicd80ja0lkclfcq8ibevgfjt