Proteomic identification of the oncoprotein STAT3 as a target of a novel Skp1 inhibitor

The S phase kinase-associated protein 1 (Skp1), an adaptor protein of the Skp1-Cul1-F-box protein complex, binds the ubiquitin E3 ligase Skp2 and is critical to its biological functions. Targeting of Skp1 by a small compound 6-O-angeloylplenolin (6-OAP) results in dissociation and degradation of Skp...

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Detalles Bibliográficos
Autores principales: Cheng, Xin, Liu, Yong-Qiang, Wang, Gui-Zhen, Yang, Li-Na, Lu, Yong-Zhi, Li, Xin-Chun, Zhou, Bo, Qu, Li-Wei, Wang, Xiao-Lu, Cheng, Yong-Xian, Liu, Jinsong, Tao, Sheng-Ce, Zhou, Guang-Biao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356833/
https://www.ncbi.nlm.nih.gov/pubmed/27835873
http://dx.doi.org/10.18632/oncotarget.13153

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