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Inhibiting the MNK-eIF4E-β-catenin axis increases the responsiveness of aggressive breast cancer cells to chemotherapy

Advanced breast cancer (eg. stage IV) is resistant to chemotherapy. In this work, we identified potentially druggable targets that are critically involved in chemoresistance. We showed that eIF4E is highly phosphorylated at serine 209 in breast cancer patients in response to chemotherapy, which sign...

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Detalles Bibliográficos
Autores principales:	Li, Zhiqiang, Sun, Yang, Qu, Miao, Wan, Hongxing, Cai, Fang, Zhang, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356851/ https://www.ncbi.nlm.nih.gov/pubmed/27926520 http://dx.doi.org/10.18632/oncotarget.13772

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