Refractory testicular germ cell tumors are highly sensitive to the second generation DNA methylation inhibitor guadecitabine

Testicular germ cell tumors (TGCTs) are the most common cancers of young males. A substantial portion of TGCT patients are refractory to cisplatin. There are no effective therapies for these patients, many of whom die from progressive disease. Embryonal carcinoma (EC) are the stem cells of TGCTs. In...

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Detalles Bibliográficos
Autores principales: Albany, Costantine, Hever-Jardine, Mary P., von Herrmann, Katherine M., Yim, Christina Y., Tam, Janice, Warzecha, Joshua M., Shin, Leah, Bock, Sarah E., Curran, Brian S., Chaudhry, Aneeq S., Kim, Fred, Sandusky, George E., Taverna, Pietro, Freemantle, Sarah J., Christensen, Brock C., Einhorn, Lawrence H., Spinella, Michael J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356854/
https://www.ncbi.nlm.nih.gov/pubmed/27936464
http://dx.doi.org/10.18632/oncotarget.13811

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