Cargando…

Pazopanib, a novel multi-kinase inhibitor, shows potent antitumor activity in colon cancer through PUMA-mediated apoptosis

Colon cancer is still the third most common cancer which has a high mortality but low five-year survival rate. Novel tyrosine kinase inhibitors (TKI) such as pazopanib become effective antineoplastic agents that show promising clinical activity in a variety of carcinoma, including colon cancer. Howe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Lingling, Wang, Huanan, Li, Wei, Zhong, Juchang, Yu, Rongcheng, Huang, Xinfeng, Wang, Honghui, Tan, Zhikai, Wang, Jiangang, Zhang, Yingjie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356882/ https://www.ncbi.nlm.nih.gov/pubmed/27924057 http://dx.doi.org/10.18632/oncotarget.13753

Ejemplares similares

Purified vitexin compound 1, a new neolignan isolated compound, promotes PUMA‐dependent apoptosis in colorectal cancer
por: Chen, Jingfei, et al.
Publicado: (2018)

PUMA mediates the combinational therapy of 5-FU and NVP-BEZ235 in colon cancer
por: Wang, Huanan, et al.
Publicado: (2015)

SIRT6 promotes autophagy through direct interaction with ULK1 and competitive binding to PUMA
por: Wu, Zhongguang, et al.
Publicado: (2022)

Enhanced growth and differentiation of myoblast cells grown on E-jet 3D printed platforms
por: Chen, Haoxiang, et al.
Publicado: (2019)

SIRT6, a novel direct transcriptional target of FoxO3a, mediates colon cancer therapy
por: Zhang, Yingjie, et al.
Publicado: (2019)

The Multi-Targeted Kinase Inhibitor Sunitinib Induces Apoptosis in Colon Cancer Cells via PUMA
por: Sun, Jing, et al.
Publicado: (2012)

Idelalisib induces PUMA-dependent apoptosis in colon cancer cells
por: Yang, Shida, et al.
Publicado: (2016)

Bengamide Analogues Show A Potent Antitumor Activity against Colon Cancer Cells: A Preliminary Study
por: García-Pinel, Beatriz, et al.
Publicado: (2020)

Lycorine Displays Potent Antitumor Efficacy in Colon Carcinoma by Targeting STAT3
por: Wu, Song, et al.
Publicado: (2018)

Blocking AMPK/ULK1-dependent autophagy promoted apoptosis and suppressed colon cancer growth
por: Liu, Jing, et al.
Publicado: (2019)

PUMA mediates the anti-cancer effect of osimertinib in colon cancer cells
por: Guo, Lingchuan, et al.
Publicado: (2017)

Trametinib with and without pazopanib has potent preclinical activity in thyroid cancer
por: BALL, DOUGLAS W., et al.
Publicado: (2015)

Targeting Gene-Viro-Therapy with AFP driving Apoptin gene shows potent antitumor effect in hepatocarcinoma
por: Zhang, Kang-Jian, et al.
Publicado: (2012)

Puma (Puma concolor) epididymal sperm morphometry
por: Cucho, Hernán, et al.
Publicado: (2016)

Morusin shows potent antitumor activity for melanoma through apoptosis induction and proliferation inhibition
por: Liu, Wei, et al.
Publicado: (2023)

Pulmonary carcinosarcoma showing an obvious response to pazopanib: a case report
por: Tanimoto, Azusa, et al.
Publicado: (2018)

Ipatasertib, a novel Akt inhibitor, induces transcription factor FoxO3a and NF-κB directly regulates PUMA-dependent apoptosis
por: Sun, Li, et al.
Publicado: (2018)

Response of pumas (Puma concolor) to migration of their primary prey in Patagonia
por: Gelin, Maria L., et al.
Publicado: (2017)

A case of Anthrax in two captive pumas (Puma concolor)
por: EKEBAS, Gorkem, et al.
Publicado: (2018)

The landscape of tyrosine kinase inhibitors in sarcomas: looking beyond pazopanib
por: Wilding, Christopher P, et al.
Publicado: (2019)

Survival and Mortality of Pumas (Puma concolor) in a Fragmented, Urbanizing Landscape
por: Vickers, T. Winston, et al.
Publicado: (2015)

The Role of Scent Marking in Mate Selection by Female Pumas (Puma concolor)
por: Allen, Maximilian L., et al.
Publicado: (2015)

Diagnostic Uncertainty and the Epidemiology of Feline Foamy Virus in Pumas (Puma concolor)
por: Dannemiller, Nicholas G., et al.
Publicado: (2020)

Dietary patterns of a versatile large carnivore, the puma (Puma concolor)
por: Karandikar, Harshad, et al.
Publicado: (2022)

Morusin shows potent antitumor activity for human hepatocellular carcinoma in vitro and in vivo through apoptosis induction and angiogenesis inhibition
por: Gao, Ling, et al.
Publicado: (2017)

Discovery of a Novel Hybrid of Vorinostat and Riluzole as a Potent Antitumor Agent
por: Xu, Qifu, et al.
Publicado: (2020)

Lobo vs puma
Publicado: (2004)

Puma strikes Bax
por: Letai, Anthony
Publicado: (2009)

Gray Hair Associated with the Multitargeted Receptor Tyrosine Kinase Inhibitor Pazopanib
por: Yun, Hwan-Jung, et al.
Publicado: (2015)

Improved Glycemic Control With the Multi-Receptor Tyrosine Kinase Inhibitor Pazopanib
por: Böhm, Steffen, et al.
Publicado: (2010)

PUMA mediates the anti-cancer effect of osimertinib in colon cancer cells [Corrigendum]
Publicado: (2018)

Antimicrobial peptides of the Cecropin-family show potent antitumor activity against bladder cancer cells
por: Suttmann, Henrik, et al.
Publicado: (2008)

Fractured Genetic Connectivity Threatens a Southern California Puma (Puma concolor) Population
por: Ernest, Holly B., et al.
Publicado: (2014)

Molecular evidence for a recent demographic expansion in the puma (Puma concolor) (Mammalia, Felidae)
por: Matte, Eunice M., et al.
Publicado: (2013)

Models of Regional Habitat Quality and Connectivity for Pumas (Puma concolor) in the Southwestern United States
por: Dickson, Brett G., et al.
Publicado: (2013)

Over-Expression of PUMA Correlates with the Apoptosis of Spinal Cord Cells in Rat Neuropathic Intermittent Claudication Model
por: Ma, Bin, et al.
Publicado: (2013)

Tyrosine Kinase Inhibitors in the Treatment of Advanced Renal Cell Carcinoma: Focus on Pazopanib
por: Vasudev, Naveen S., et al.
Publicado: (2011)

Cross-resistance to clinically used tyrosine kinase inhibitors sunitinib, sorafenib and pazopanib
por: Gotink, Kristy J., et al.
Publicado: (2015)

CXCL11-Armed oncolytic poxvirus elicits potent antitumor immunity and shows enhanced therapeutic efficacy
por: Liu, Zuqiang, et al.
Publicado: (2015)

PUMA: antiprotons and radioactive nuclei
por: Aumann, T, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_5tm29urn6hpibd702m13fthcsn