Oncolytic virus synergizes with Smac mimetic compounds to induce rhabdomyosarcoma cell death in a syngeneic murine model

Rhabdomyosarcoma (RMS), a neoplasm characterized by undifferentiated myoblasts, is the most common soft tissue tumour in children. Therapeutic resistance is common in RMS and is often caused by acquired defects in the cellular apoptotic program. Smac mimetic compounds (SMCs) are a novel class of inh...

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Detalles Bibliográficos
Autores principales: Dobson, Christine C, Naing, Thet, Beug, Shawn T, Faye, Mame D, Chabot, Janelle, St-Jean, Martin, Walker, Danielle E, LaCasse, Eric C, Stojdl, David F, Korneluk, Robert G, Holcik, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356898/
https://www.ncbi.nlm.nih.gov/pubmed/27966453
http://dx.doi.org/10.18632/oncotarget.13849

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