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Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation
Soluble fibrinogen-like protein 2 (sFGL2) is the soluble form of fibrinogen-like protein 2 belonging to the fibrinogen-related protein superfamily. It is now well characterized that sFGL2 is mainly secreted by regulatory T cell (Treg) populations, and exerts potently immunosuppressive activities. By...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356913/ https://www.ncbi.nlm.nih.gov/pubmed/27732962 http://dx.doi.org/10.18632/oncotarget.12533 |
_version_ | 1782515947007901696 |
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author | Liu, Xin-guang Liu, Yu Chen, Feng |
author_facet | Liu, Xin-guang Liu, Yu Chen, Feng |
author_sort | Liu, Xin-guang |
collection | PubMed |
description | Soluble fibrinogen-like protein 2 (sFGL2) is the soluble form of fibrinogen-like protein 2 belonging to the fibrinogen-related protein superfamily. It is now well characterized that sFGL2 is mainly secreted by regulatory T cell (Treg) populations, and exerts potently immunosuppressive activities. By repressing not only the differentiation and proliferation of T cells but also the maturation of dendritic cells (DCs), sFGL2 acts largely as an immunosuppressant. Moreover, sFGL2 also induces apoptosis of B cells, tubular epithelial cells (TECs), sinusoidal endothelial cells (SECs), and hepatocytes. This mini-review focuses primarily on the recent literature with respect to the signaling mechanism of sFGL2 in immunomodulation, and discusses the clinical implications of sFGL2 in transplantation, hepatitis, autoimmunity, and tumors. |
format | Online Article Text |
id | pubmed-5356913 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2016 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-53569132017-04-20 Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation Liu, Xin-guang Liu, Yu Chen, Feng Oncotarget Review Soluble fibrinogen-like protein 2 (sFGL2) is the soluble form of fibrinogen-like protein 2 belonging to the fibrinogen-related protein superfamily. It is now well characterized that sFGL2 is mainly secreted by regulatory T cell (Treg) populations, and exerts potently immunosuppressive activities. By repressing not only the differentiation and proliferation of T cells but also the maturation of dendritic cells (DCs), sFGL2 acts largely as an immunosuppressant. Moreover, sFGL2 also induces apoptosis of B cells, tubular epithelial cells (TECs), sinusoidal endothelial cells (SECs), and hepatocytes. This mini-review focuses primarily on the recent literature with respect to the signaling mechanism of sFGL2 in immunomodulation, and discusses the clinical implications of sFGL2 in transplantation, hepatitis, autoimmunity, and tumors. Impact Journals LLC 2016-10-08 /pmc/articles/PMC5356913/ /pubmed/27732962 http://dx.doi.org/10.18632/oncotarget.12533 Text en Copyright: © 2017 Liu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Review Liu, Xin-guang Liu, Yu Chen, Feng Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation |
title | Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation |
title_full | Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation |
title_fullStr | Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation |
title_full_unstemmed | Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation |
title_short | Soluble fibrinogen like protein 2 (sFGL2), the novel effector molecule for immunoregulation |
title_sort | soluble fibrinogen like protein 2 (sfgl2), the novel effector molecule for immunoregulation |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356913/ https://www.ncbi.nlm.nih.gov/pubmed/27732962 http://dx.doi.org/10.18632/oncotarget.12533 |
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